Several diseases associated with high-altitude exposure affect unacclimated individuals.
These diseases include acute mountain sickness (AMS), high-altitude cerebral edema …

It has been known for more than 60 years, and suspected for over 100, that alveolar hypoxia
causes pulmonary vasoconstriction by means of mechanisms local to the lung. For the last …

All metazoans depend on the consumption of O2 by the mitochondrial oxidative
phosphorylation system (OXPHOS) to produce energy. In addition, the OXPHOS uses O2 to …

Significance: Fluorescent protein sensors have revitalized the field of redox biology by
revolutionizing the study of redox processes in living cells and organisms. Recent Advances …

Mitochondria can govern local concentrations of second messengers, such as reactive
oxygen species (ROS), and mitochondrial translocation to discrete subcellular regions may …

Redox biochemistry is increasingly recognized as an integral component of cellular signal
processing and cell fate decision making. Unfortunately, our capabilities to observe and …

Organisms that tolerate wide variations in oxygen availability, especially to hypoxia, usually
face harsh environmental conditions during their lives. Such conditions include, for example …

Hypoxia triggers a wide range of protective responses in mammalian cells, which are
mediated through transcriptional and post-translational mechanisms. Redox signaling in …

Reactive oxygen species (ROS) formation and signaling are of major importance and
regulate a number of processes in physiological conditions. A disruption in redox status …

Hypoxic pulmonary vasoconstriction (HPV), also known as the von Euler–Liljestrand
mechanism, is an essential response of the pulmonary vasculature to acute and sustained …