Green tea catechins: Their use in treating and preventing infectious diseases

WC Reygaert - BioMed research international, 2018 - Wiley Online Library
Green tea is one of the most popular drinks consumed worldwide. Produced mainly in Asian
countries from the leaves of the Camellia sinensis plant, the potential health benefits have …

Plant polyphenols: chemical properties, biological activities, and synthesis

S Quideau, D Deffieux… - Angewandte Chemie …, 2011 - Wiley Online Library
Eating five servings of fruits and vegetables per day! This is what is highly recommended
and heavily advertised nowadays to the general public to stay fit and healthy! Drinking green …

Structure-based discovery of small molecules that disaggregate Alzheimer's disease tissue derived tau fibrils in vitro

PM Seidler, KA Murray, DR Boyer, P Ge… - Nature …, 2022 - nature.com
Alzheimer's disease (AD) is the consequence of neuronal death and brain atrophy
associated with the aggregation of protein tau into fibrils. Thus disaggregation of tau fibrils …

The tip of the iceberg: RNA-binding proteins with prion-like domains in neurodegenerative disease

OD King, AD Gitler, J Shorter - Brain research, 2012 - Elsevier
Prions are self-templating protein conformers that are naturally transmitted between
individuals and promote phenotypic change. In yeast, prion-encoded phenotypes can be …

EGCG remodels mature α-synuclein and amyloid-β fibrils and reduces cellular toxicity

J Bieschke, J Russ, RP Friedrich… - Proceedings of the …, 2010 - National Acad Sciences
Protein misfolding and formation of β-sheet-rich amyloid fibrils or aggregates is related to
cellular toxicity and decay in various human disorders including Alzheimer's and Parkinson's …

Amyloid assembly and disassembly

E Chuang, AM Hori, CD Hesketh… - Journal of Cell …, 2018 - journals.biologists.com
Amyloid fibrils are protein homopolymers that adopt diverse cross-β conformations. Some
amyloid fibrils are associated with the pathogenesis of devastating neurodegenerative …

[HTML][HTML] Prion-like domains as epigenetic regulators, scaffolds for subcellular organization, and drivers of neurodegenerative disease

ZM March, OD King, J Shorter - Brain research, 2016 - Elsevier
Key challenges faced by all cells include how to spatiotemporally organize complex
biochemistry and how to respond to environmental fluctuations. The budding yeast …

Features of protein–protein interactions that translate into potent inhibitors: topology, surface area and affinity

MC Smith, JE Gestwicki - Expert reviews in molecular medicine, 2012 - cambridge.org
Protein–protein interactions (PPIs) control the assembly of multi-protein complexes and,
thus, these contacts have enormous potential as drug targets. However, the field has …

Recent perspectives on the molecular basis of biofilm formation by Pseudomonas aeruginosa and approaches for treatment and biofilm dispersal

S Skariyachan, VS Sridhar, S Packirisamy… - Folia microbiologica, 2018 - Springer
Pseudomonas aeruginosa, a Gram-negative, rod-shaped bacterium causes widespread
diseases in humans. This bacterium is frequently related to nosocomial infections such as …

General principles underpinning amyloid structure

AIP Taylor, RA Staniforth - Frontiers in Neuroscience, 2022 - frontiersin.org
Amyloid fibrils are a pathologically and functionally relevant state of protein folding, which is
generally accessible to polypeptide chains and differs fundamentally from the globular state …