Diabetes mellitus is a metabolic disorder that affects more than 460 million people
worldwide. Type 1 diabetes (T1D) is caused by autoimmune destruction of β-cells, whereas …

Human embryonic stem cells (hESC) and induced pluripotent stem cells (hiPSC) are
considered attractive sources of pancreatic β cells and islet organoids. Recently, several …

Background Insulin‐secreting cells have been generated from human embryonic or induced
pluripotent stem cells (iPSCs) by mimicking developmental processes. However, these cells …

Diabetes mellitus type 1 and type 2 have become a global epidemic with dramatically
increasing incidences. Poorly controlled diabetes is associated with severe life-threatening …

The development of new therapeutic approaches to treat type 1 diabetes mellitus (T1D)
relies on the precise understanding and deciphering of insulin-secreting β-cell biology, as …

With the increase in knowledge resulting from the sequencing of the human genome, the
genetic basis for the underlying differences in individuals, their diseases, and how they …

The directed differentiation of human pluripotent stem cells, such as embryonic stem cells
(hESC s) and induced pluripotent stem cells (hi PSC s), into pancreatic endocrine lineages …

Canine mesenchymal stem cells (cMSCs) have potential applications for regenerative
therapy, including the generation of insulin-producing cells (IPCs) for studying and treating …

Background The liver as transplantation site for human pancreatic islets is a harsh
microenvironment for islets and it lacks the ability to retrieve the graft. A retrievable …

Several distinct differentiation protocols for deriving pancreatic progenitors (PPs) from
human pluripotent stem cells have been described, but it remains to be shown how similar …