End-stage organ failure can result from various preexisting conditions and occurs in patients
of all ages, and organ transplantation remains its only treatment. In recent years, extensive …

Developing functional organs from stem cells remains a challenging goal in regenerative
medicine. Existing methodologies, such as tissue engineering, bioprinting, and organoids …

Many thousands and, in some cases, millions of individuals from the major crop and
livestock species have been genotyped and phenotyped for the purpose of genomic …

Xenotransplantation represents a possible solution to the organ shortage crisis and is an
imminent clinical reality with long-term xenograft survival in pig-to-nonhuman primate (NHP) …

Notable progress in basic, translational and clinical nephrology research has been made
over the past five decades. Nonetheless, many challenges remain, including obstacles to …

The recent sad death of Mr. Lawrence Faucette, the second patient to undergo pig heart
transplantation at the University of Maryland at Baltimore (UMB), is a significant setback to …

Allogeneic cellular immunotherapies hold a great promise for cancer treatment owing to
their potential cost-effectiveness, scalability and on-demand availability. However, immune …

An estimated 1.5 million Americans suffer from Type I diabetes mellitus, and its incidence is
increasing worldwide. Islet allotransplantation offers a treatment, but the availability of …

Genetic modification of porcine donors, combined with optimized immunosuppression, has
been shown to improve outcomes of experimental xenotransplant. However, little is known …

Among strategies to limit ischemia/reperfusion (IR) injuries in transplantation, cell therapy
using stem cells to condition/repair transplanted organs appears promising. We …