Objective To review the basic scientific status of repair in articular cartilage tissue and to
assess the efficiency of current clinical therapies instigated for the treatment of structural …

Mesenchymal stem sells (MSCs) are present in a variety of tissues during human
development, and in adults they are prevalent in bone marrow. From that readily available …

Recent studies have demonstrated the existence of a subset of cells in human bone marrow
capable of differentiating along multiple mesenchymal lineages. Not only do these …

Age-related decrease in bone formation is well described. However, the cellular causes are
not known. Thus, we have established cultures of bone marrow stromal cells (MSC) from …

Complex interactions among cells of the monocyte-macrophage-osteoclast lineage and the
mesenchymal stem cell-osteoblast lineage play a major role in the pathophysiology of bone …

The premise that bones grow and remodel throughout life to adapt to their mechanical
enironment is often called Wolff's law. Wolff's law, however, is not always true, and in fact …

Background: Bone marrow aspirated from the iliac crest contains progenitor cells that can be
used to obtain bone-healing of nonunions. However, there is little available information …

Bone marrow stromal cells can give rise to several mesenchymal lineages. The existence of
a common stem/progenitor cell, the mesenchymal stem cell, has been proposed, but which …

Abstract More than 2.1 million age-related fractures occur in the United States annually,
resulting in an immense socioeconomic burden. Importantly, the age-related deterioration of …

The role of adult mesenchymal stem cells (MSC) in tissue maintenance and regeneration
has received significant attention of late. Questions arise to what extent these cells are either …