Abstract Interleukin-1, an inflammatory cytokine, is considered to have diverse physiological
functions and pathological significances and play an important role in health and disease. In …

Abstract Interleukin-1 (IL-1) is a highly active pro-inflammatory cytokine that lowers pain
thresholds and damages tissues. Monotherapy blocking IL-1 activity in autoinflammatory …

IL-1 is a master cytokine of local and systemic inflammation. With the availability of specific
IL-1 targeting therapies, a broadening list of diseases has revealed the pathologic role of IL …

Over recent years it has become increasingly clear that innate immune responses can
shape the adaptive immune response. Among the most potent molecules of the innate …

An expanding spectrum of acute and chronic non‐infectious inflammatory diseases is
uniquely responsive to IL‐1β neutralization. IL‐1β‐mediated diseases are often called “auto …

Growing knowledge about the cytokine network response has led to a better comprehension
of mechanisms of pathologies and to the development of new treatments with biological …

The autoinflammatory diseases are characterized by seemingly unprovoked episodes of
inflammation, without high-titer autoantibodies or antigen-specific T cells. The concept was …

The NOD-like receptors (NLRs) are a specialized group of intracellular receptors that
represent a key component of the host innate immune system. Since the discovery of the first …

Missense mutations in the C-terminal B30. 2 domain of pyrin cause familial Mediterranean
fever (FMF), the most common Mendelian autoinflammatory disease. However, it remains …

Familial Mediterranean fever (FMF) is the most common monogenic autoinflammatory
disease (AID) affecting mainly the ethnic groups originating from Mediterranean basin. The …