Hypoxia is a common feature of solid tumors, and develops because of the rapid growth of
the tumor that outstrips the oxygen supply, and impaired blood flow due to the formation of …

Abnormal regulation and expression of microRNAs (miRNAs) has been documented in
various diseases including cancer. The miRNA let-7 (MIRLET7) family controls …

Background Circulating cell-free miRNAs have emerged as promising minimally-invasive
biomarkers for early detection, prognosis and monitoring of cancer. They can exist in the …

Enhancer of zeste homolog 2 (EZH2) is the histone lysine N-methyltransferase component
of the Polycomb repressive complex 2 (PRC2), which, in conjunction with embryonic …

The identification of small subpopulations of cancer stem cells (CSCs) from blood
mononuclear cells in human acute myeloid leukemia (AML) in 1997 was a landmark …

Meningiomas are mostly benign brain tumours, with a potential for becoming atypical or
malignant. On the basis of comprehensive genomic, transcriptomic and epigenomic …

Therapy-induced neuroendocrine prostate cancer (t-NEPC) is a highly aggressive subtype
of prostate cancer with poor patient survival. Emerging evidence indicates that t-NEPC can …

Abstract Polycomb repressive complex 2 (PRC2) is the epigenetic regulator that induces
histone H3 lysine 27 methylation (H3K27me3) and silences specific gene transcription …

Background Prostate cancer threatens the health of men over sixty years old, and its
incidence ranks first among all urinary tumors among men. Enzalutamide remains the first …

Prostate cancer (PCa) is the second most common cancer in men worldwide. A large
proportion of PCa are latent, never destined to progress or affect the patients' life. It is of …