Lamins are intermediate filament proteins that form a scaffold, termed nuclear lamina, at the
nuclear periphery. A small fraction of lamins also localize throughout the nucleoplasm …

The nuclear lamina is an important structural determinant for the nuclear envelope as a
whole, attaching chromatin domains to the nuclear periphery and localizing some nuclear …

Ageing is intimately connected to the induction of cell senescence,, but why this is so
remains poorly understood. A key challenge is the identification of pathways that normally …

Cellular senescence contributes to age-related disorders including physical dysfunction,
disabilities, and mortality caused by tissue inflammation and damage. Senescent cells …

Macroautophagy (hereafter referred to as autophagy) is a catabolic membrane trafficking
process that degrades a variety of cellular constituents and is associated with human …

During mitotic exit, missegregated chromosomes can recruit their own nuclear envelope
(NE) to form micronuclei (MN). MN have reduced functioning compared to primary nuclei in …

Cellular senescence is a potent tumor-suppressive mechanism that arrests cell proliferation
and has been linked to aging. However, studies of senescence have been impeded by the …

Cellular senescence is a stable proliferation arrest, a potent tumor suppressor mechanism,
and a likely contributor to tissue aging. Cellular senescence involves extensive cellular …

Intron retention (IR) is widely recognized as a consequence of mis-splicing that leads to
failed excision of intronic sequences from pre-messenger RNAs. Our bioinformatic analyses …

Nuclear lamin B1 (LB1) is a major structural component of the nucleus that appears to be
involved in the regulation of many nuclear functions. The results of this study demonstrate …