Role of the PADI family in inflammatory autoimmune diseases and cancers: A systematic review
C Zhu, C Liu, Z Chai - Frontiers in Immunology, 2023 - frontiersin.org
The peptidyl arginine deiminase (PADI) family is a calcium ion-dependent group of
isozymes with sequence similarity that catalyze the citrullination of proteins. Histones can …
isozymes with sequence similarity that catalyze the citrullination of proteins. Histones can …
Prevalence of autoimmune diseases and clinical significance of autoantibody profile: Data from National Institute of Hygiene in Rabat, Morocco
H Missoum, M Alami, F Bachir, N Arji, A Bouyahya… - Human immunology, 2019 - Elsevier
Aim The objective of this study was to explore the prevalence of various autoimmune
diseases (AIDs) in a large cohort of patients and to characterize the autoantibody profile in …
diseases (AIDs) in a large cohort of patients and to characterize the autoantibody profile in …
Association of PADI4 Gene Polymorphisms With Susceptibility to Rheumatoid Arthritis: Evidence From 24 Case–Control Studies
M Karimian… - International Journal of …, 2024 - Wiley Online Library
This study aims to investigate the association of rs11203366, rs11203367, rs874881,
rs2240340 and rs1748033 polymorphisms of protein‐arginine deiminase type 4 (PADI4) …
rs2240340 and rs1748033 polymorphisms of protein‐arginine deiminase type 4 (PADI4) …
PADI4 Haplotypes Contribute to mRNA Expression, the Enzymatic Activity of Peptidyl Arginine Deaminase and Rheumatoid Arthritis Risk in Patients from Western …
MG Matuz-Flores, JA Rosas-Rodríguez… - Current issues in …, 2022 - mdpi.com
Citrullination is catalyzed by the peptidyl arginine deiminase 4 (PAD4) enzyme, encoded by
the PADI4 gene. Increased PAD4 activity promotes the onset and progression of rheumatoid …
the PADI4 gene. Increased PAD4 activity promotes the onset and progression of rheumatoid …
Implications of Peptidyl Arginine Deiminase 4 gene transcription and polymorphisms in susceptibility to rheumatoid arthritis in an Iranian population
Z Bagheri-Hosseinabadi, MR Mirzaei, O Esmaeili… - BMC Medical …, 2023 - Springer
Background Peptidyl arginine deiminase 4 (PADI4) has been implicated in Rheumatoid
arthritis (RA) pathogenesis. Here we aimed to evaluate the association of PADI4 gene …
arthritis (RA) pathogenesis. Here we aimed to evaluate the association of PADI4 gene …
Novel functional polymorphism on PADI-4 gene and its association with arthritis onset
D Maryam Mukhtar, D Nadeem Sheikh… - Saudi Journal of …, 2021 - pmc.ncbi.nlm.nih.gov
Background Citrullinated proteins formed by peptidyl arginine deiminases (PADIs)
deimination of arginine residues in proteins are of particular interest in arthritis …
deimination of arginine residues in proteins are of particular interest in arthritis …
PADI2 Polymorphisms Are Significantly Associated With Rheumatoid Arthritis, Autoantibodies Serologic Status and Joint Damage in Women from Southern Mexico
IP Guzmán-Guzmán, CI Ramírez-Vélez… - Frontiers in …, 2021 - frontiersin.org
The enzymes of the family peptidylarginine deiminases (PADs) have an important role in the
pathogenesis of rheumatoid arthritis (RA) due to their association with the anti-citrullinated …
pathogenesis of rheumatoid arthritis (RA) due to their association with the anti-citrullinated …
Association of PADI2 and PADI4 polymorphisms in COVID-19 host severity and non-survival
IA Gutiérrez-Pérez, I Buendía-Roldán… - Heliyon, 2024 - cell.com
Background Enzymes of the peptidylarginine deiminase family (PADs) play a relevant role in
the pathogenesis of COVID-19. However, the association of single nucleotide …
the pathogenesis of COVID-19. However, the association of single nucleotide …
A common missense variant rs874881 of PADI4 gene and rheumatoid arthritis: Genetic association study and in-silico analysis
M Bashir, W Mateen, S Khurshid, JM Malik, Z Agha… - Gene, 2023 - Elsevier
Abstract The peptidylarginine-deiminase 4 (PADI4) is involved in the post-translational
catalytic conversion of arginine into citrulline. The autoantibodies including anti-citrullinated …
catalytic conversion of arginine into citrulline. The autoantibodies including anti-citrullinated …
Genetic and Clinical Factors Associated with Olokizumab Treatment in Russian Patients with Rheumatoid Arthritis
DS Mikhaylenko, EB Kuznetsova, VV Musatova… - Journal of Personalized …, 2022 - mdpi.com
Rheumatoid arthritis (RA) is a chronic systemic inflammatory disease and its treatment is an
urgent problem of rheumatology. Olokizumab (OKZ) is a new humanized monoclonal …
urgent problem of rheumatology. Olokizumab (OKZ) is a new humanized monoclonal …