The cell-autonomous innate immune system enables animal cells to resist viral infection.
This system comprises an array of sensors that, after detecting viral molecules, activate the …

Argonaute proteins (Agos) use small 15–30 nucleotide-long guides to bind and/or cleave
complementary target nucleic acids. Eukaryotic Agos mediate RNA-guided RNA silencing …

Although eukaryotic and long prokaryotic Argonaute proteins (pAgos) cleave nucleic acids,
some short pAgos lack nuclease activity and hydrolyse NAD (P)+ to induce bacterial cell …

Both eukaryotes and prokaryotes (archaea and bacteria) encode an arsenal of immune
systems that protect the host against mobile genetic elements (MGEs) including viruses …

Members of the conserved Argonaute protein family use small RNA guides to locate their
mRNA targets and regulate gene expression and suppress mobile genetic elements in …

Argonaute proteins are programmable nucleases that have defense and regulatory
functions in both eukaryotes and prokaryotes. All known prokaryotic Argonautes (pAgos) …

Over the past few decades, pathogens have posed a threat to human security, and rapid
identification of pathogens should be one of the ideal methods to prevent major public …

In the present study, we upgraded Pyrococcus furiosus Argonaute (PfAgo) mediated nucleic
acid detection method and established a highly sensitive and accurate molecular diagnosis …

In many eukaryotes, Argonaute proteins, guided by short RNA sequences, defend cells
against transposons and viruses. In the eubacterium Thermus thermophilus, the DNA …

Argonaute proteins (Agos) bind short nucleic acids as guides and are directed by them to
recognize target complementary nucleic acids. Diverse prokaryotic Agos (pAgos) play …