Angiogenesis is a process associated with the migration and proliferation of endothelial
cells (EC) to form new blood vessels. It is involved in various physiological and …

Fibrosis is known as a frequent and irreversible pathological condition which is associated
with organ failure. Tissue fibrosis is a central process in a variety of chronic progressive …

Despite its function as an inhibitor of urokinase and tissue-type plasminogen activator (PA),
PA inhibitor-1 (PAI-1) has a paradoxical protumorigenic role in cancer, promoting …

The interaction of the plasma protein vitronectin with plasminogen activator inhibitor-1 (PAI-
1) is central to human health. Vitronectin binding extends the lifetime of active PAI-1, which …

The plasminogen system is a critical proteolytic system responsible for the remodeling of the
extracellular matrix (ECM). The master regulator of the plasminogen system, plasminogen …

Obstructive sleep apnea is a chronic and prevalent condition that is associated with
endothelial dysfunction, atherosclerosis, and imposes excess overall cardiovascular risk …

The extracellular matrix (ECM) is a complex structural entity surrounding and supporting
cells present in all tissue and organs. Cell–matrix interactions play fundamental roles during …

Lubricin, a protein product of the gene PRG4, is a secreted mucin-like proteoglycan that is a
major lubricant in articulating joints. Mutations in PRG4 cause the autosomal recessive …

The pathogenesis of pulmonary fibrosis is thought to involve alveolar epithelial injury that,
when successfully repaired, can limit subsequent scarring. The plasminogen system …

Haemophilus influenzae protein E (PE) is a 16 kDa adhesin that induces a pro‐inflammatory
immune response in lung epithelial cells. The active epithelial binding region comprising …