Neuroinflammation following traumatic brain injury: take it seriously or not

R Zheng, K Lee, Z Qi, Z Wang, Z Xu, X Wu… - Frontiers in …, 2022 - frontiersin.org
Traumatic brain injury (TBI) is associated with high mortality and disability, with a substantial
socioeconomic burden. With the standardization of the treatment process, there is increasing …

Identifying the phenotypes of diffuse axonal injury following traumatic brain injury

JL Krieg, AV Leonard, RJ Turner, F Corrigan - Brain sciences, 2023 - mdpi.com
Diffuse axonal injury (DAI) is a significant feature of traumatic brain injury (TBI) across all
injury severities and is driven by the primary mechanical insult and secondary biochemical …

Diffusion tensor imaging and plasma immunological biomarker panel in a rat traumatic brain injury (TBI) model and in human clinical TBI

XV To, AZ Mohamed, P Cumming… - Frontiers in …, 2024 - frontiersin.org
Introduction Neuroinflammatory reactions play a significant role in the pathology and long-
term consequences of traumatic brain injury (TBI) and may mediate salutogenic processes …

[HTML][HTML] Evaluating the effect of post-traumatic hypoxia on the development of axonal injury following traumatic brain injury in sheep

JM Sharkey, RD Quarrington, JL Krieg, L Kaukas… - Brain Research, 2023 - Elsevier
Damage to the axonal white matter tracts within the brain is a key cause of neurological
impairment and long-term disability following traumatic brain injury (TBI). Understanding …

Traumatic brain injury augurs ill for prolonged deficits in the brain's structural and functional integrity following controlled cortical impact injury

AZ Mohamed, P Cumming, FA Nasrallah - Scientific reports, 2021 - nature.com
Previous neuroimaging studies in rodents investigated effects of the controlled cortical
impact (CCI) model of traumatic brain injury (TBI) within one-month post-TBI. This study …

Characterization of traumatic brain injury in a gyrencephalic ferret model using the novel closed head injury model of engineered rotational acceleration (CHIMERA)

JL Krieg, AV Leonard, RJ Tuner, F Corrigan - Neurotrauma Reports, 2023 - liebertpub.com
Traumatic brain injury (TBI) results from mechanical force to the brain and leads to a series
of biochemical responses that further damage neurons and supporting cells. Clinically, most …

Evolving brain and behaviour changes in rats following repetitive subconcussive head impacts

WS Hoogenboom, TG Rubin, K Ambadipudi… - Brain …, 2023 - academic.oup.com
There is growing concern that repetitive subconcussive head impacts, independent of
concussion, alter brain structure and function, and may disproportionately affect the …

CORM-3 ameliorates neurodegeneration in the amygdala and improves depression-and anxiety-like behavior in a rat model of combined traumatic brain injury and …

Y Li, LM Zhang, DX Zhang, WC Zheng, Y Bai… - Neurochemistry …, 2020 - Elsevier
Objective Emotional disturbances characterized by depression and anxiety among survivors
of traumatic brain injury (TBI) impact the quality of life severely. Currently, there is a lack of …

Finding the spatial co-variation of brain deformation with principal component analysis

X Zhan, Y Liu, NJ Cecchi, O Gevaert… - IEEE Transactions …, 2022 - ieeexplore.ieee.org
Objective: Strain and strain rate are effective traumatic brain injury metrics. In finite element
(FE) head model, thousands of elements were used to represent the spatial distribution of …

Initial Severity of Injury Has Little Effect on the Temporal Profile of Long-Term Deficits in Locomotion, Anxiety, and Cognitive Function After Diffuse Traumatic Brain …

F Corrigan, A Arulsamy, SR Shultz, DK Wright… - Neurotrauma …, 2023 - liebertpub.com
Traumatic brain injury (TBI) is associated with persistent impairments in multiple domains,
including cognitive and neuropsychiatric function. Previous literature has suggested that the …