Macrophages: Their role, activation and polarization in pulmonary diseases

S Arora, K Dev, B Agarwal, P Das, MA Syed - Immunobiology, 2018 - Elsevier
Macrophages, circulating in the blood or concatenated into different organs and tissues
constitute the first barrier against any disease. They are foremost controllers of both innate …

Macrophage: a cell with many faces and functions in tuberculosis

F Ahmad, A Rani, A Alam, S Zarin, S Pandey… - Frontiers in …, 2022 - frontiersin.org
Mycobacterium tuberculosis (Mtb) is the causative agent of human tuberculosis (TB) which
primarily infects the macrophages. Nearly a quarter of the world's population is infected …

Role of apoptosis and autophagy in tuberculosis

A Lam, R Prabhu, CM Gross… - … of Physiology-Lung …, 2017 - journals.physiology.org
Tuberculosis (TB) is one of the oldest known human diseases and is transmitted by the
bacteria Mycobacterium tuberculosis (Mtb). TB has a rich history with evidence of TB …

Natural and trained innate immunity against Mycobacterium tuberculosis

J Ferluga, H Yasmin, MN Al-Ahdal, S Bhakta, U Kishore - Immunobiology, 2020 - Elsevier
Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb) infection, remains a major
global health emergency. It is estimated that one third of global population are affected …

Hacking the host: exploitation of macrophage polarization by intracellular bacterial pathogens

JD Thiriot, YB Martinez-Martinez… - Pathogens and …, 2020 - academic.oup.com
Macrophages play an integral role in host defenses against intracellular bacterial
pathogens. A remarkable plasticity allows for adaptation to the needs of the host to …

The Role of microRNAs and Long Non-Coding RNAs in the Regulation of the Immune Response to Mycobacterium tuberculosis Infection

M Kundu, J Basu - Frontiers in immunology, 2021 - frontiersin.org
Non-coding RNAs have emerged as critical regulators of the immune response to infection.
MicroRNAs (miRNAs) are small non-coding RNAs which regulate host defense mechanisms …

Reinventing the human tuberculosis (TB) granuloma: Learning from the cancer field

S Ashenafi, S Brighenti - Frontiers in Immunology, 2022 - frontiersin.org
Tuberculosis (TB) remains one of the deadliest infectious diseases in the world and every 20
seconds a person dies from TB. An important attribute of human TB is induction of a …

STAT1 and its related molecules as potential biomarkers in Mycobacterium tuberculosis infection

X Yi, B Zhang, Y Fu, Z Yi - Journal of Cellular and Molecular …, 2020 - Wiley Online Library
Tuberculosis (TB) is a severe infectious disease that seriously endangers human health.
The immune defence mechanism of the body against TB is still unclear. The purpose of this …

Preventing acute lung injury from progressing to pulmonary fibrosis by maintaining ERS homeostasis through a multistage targeting nanomicelle

L Luo, Z Luo, J Zhang, X Liu, J Huang, S Wang, H Yin… - Nano Today, 2023 - Elsevier
Acute lung injury/acute respiratory distress syndrome (ALI/ARDS) or pulmonary fibrosis (PF)
has been regarded as a global health issue with high mortality and limited drug therapy …

BAG2 ameliorates endoplasmic reticulum stress-induced cell apoptosis in Mycobacterium tuberculosis-infected macrophages through selective autophagy

S Liang, F Wang, C Bao, J Han, Y Guo, F Liu, Y Zhang - Autophagy, 2020 - Taylor & Francis
ABSTRACT BAG2 (BCL2 associated athanogene 2) is associated with cell fate
determination in response to various pathological conditions. However, the effects of BAG2 …