Role of protein kinase CK2 in antitumor drug resistance
Drug resistance represents the major reason of pharmacological treatment failure. It is
supported by a broad spectrum of mechanisms, whose molecular bases have been …
supported by a broad spectrum of mechanisms, whose molecular bases have been …
Targeting breast cancer resistance protein (BCRP/ABCG2): Functional inhibitors and expression modulators
IF Zattoni, LC Delabio, J de Paula Dutra, DH Kita… - European journal of …, 2022 - Elsevier
The primary source of failure of cancer therapies is multidrug resistance (MDR), which can
be caused by different mechanisms, including the overexpression of ABC transporters in …
be caused by different mechanisms, including the overexpression of ABC transporters in …
ADMET evaluation in drug discovery. 20. Prediction of breast cancer resistance protein inhibition through machine learning
Breast cancer resistance protein (BCRP/ABCG2), an ATP-binding cassette (ABC) efflux
transporter, plays a critical role in multi-drug resistance (MDR) to anti-cancer drugs and drug …
transporter, plays a critical role in multi-drug resistance (MDR) to anti-cancer drugs and drug …
The multidrug transporter ABCG2: still more questions than answers
AJ Horsey, MH Cox, S Sarwat… - Biochemical Society …, 2016 - portlandpress.com
ABCG2 is one of at least three human ATP binding cassette (ABC) transporters which can
facilitate the export from cells of a wide range of chemically unrelated drug molecules. This …
facilitate the export from cells of a wide range of chemically unrelated drug molecules. This …
Synthesis and biological investigation of 2, 4-substituted quinazolines as highly potent inhibitors of breast cancer resistance protein (ABCG2)
MK Krapf, J Gallus, M Wiese - European journal of medicinal chemistry, 2017 - Elsevier
Expression of ABCG2, a member of the ABC transporter superfamily, has been correlated to
the clinical outcome of multiple cancers and is often associated with the occurrence of …
the clinical outcome of multiple cancers and is often associated with the occurrence of …
Mechanistic basis of breast cancer resistance protein inhibition by new indeno[1,2-b]indoles
DH Kita, N Guragossian, IF Zattoni, VR Moure… - Scientific Reports, 2021 - nature.com
The ATP-binding cassette transporter ABCG2 mediates the efflux of several
chemotherapeutic drugs, contributing to the development of multidrug resistance (MDR) in …
chemotherapeutic drugs, contributing to the development of multidrug resistance (MDR) in …
4-Anilino-2-pyridylquinazolines and-pyrimidines as highly potent and nontoxic inhibitors of breast cancer resistance protein (ABCG2)
MK Krapf, J Gallus, M Wiese - Journal of medicinal chemistry, 2017 - ACS Publications
Multidrug resistance (MDR) mediated by ATP-binding cassette (ABC) transport proteins
remains a major problem in the chemotherapeutic treatment of cancer and might be …
remains a major problem in the chemotherapeutic treatment of cancer and might be …
Gene-gene and gene-environment interactions influence platinum-based chemotherapy response and toxicity in non-small cell lung cancer patients
JJ Cui, LY Wang, T Zhu, WJ Gong, HH Zhou, ZQ Liu… - Scientific reports, 2017 - nature.com
Platinum-based chemotherapy is a major therapeutic regimen of lung cancer. Various single
nucleotide polymorphisms (SNPs) reported were associated with platinum-based …
nucleotide polymorphisms (SNPs) reported were associated with platinum-based …
Water-soluble inhibitors of ABCG2 (BCRP)–a fragment-based and computational approach
F Antoni, D Wifling, G Bernhardt - European Journal of Medicinal Chemistry, 2021 - Elsevier
A good balance between hydrophilicity and lipophilicity is a prerequisite for all bioactive
compounds. If the hydrophilicity of a compound is low, its solubility in water will be meager …
compounds. If the hydrophilicity of a compound is low, its solubility in water will be meager …
Development of Pharmacophore Model for Indeno[1,2-b]indoles as Human Protein Kinase CK2 Inhibitors and Database Mining
Protein kinase CK2, initially designated as casein kinase 2, is an ubiquitously expressed
serine/threonine kinase. This enzyme, implicated in many cellular processes, is highly …
serine/threonine kinase. This enzyme, implicated in many cellular processes, is highly …