Kv7. 2 subunits encoded by the KCNQ2 gene constitute a critical molecular component of
the M-current, a subthreshold voltage-gated potassium current controlling neuronal …

Autism spectrum disorder (ASD) comprises a group of neurodevelopmental disorders
characterized by impaired social interaction and communication, and restricted, repetitive …

Abstract Background Neural stem cells (NSCs) are considered as candidates for cell
replacement therapy in many neurological disorders. However, the propensity for their …

Microglia are resident tissue macrophages of the central nervous system (CNS) that arise
from erythromyeloid progenitors during embryonic development. They play essential roles in …

Huntington's disease (HD) is an inherited neurodegenerative disorder in which the striatum
is the most affected brain region. Although a chronic inflammatory microglial reaction that …

Myoclonus dystonia is a childhood-onset hyperkinetic movement disorder with a combined
motor and psychiatric phenotype. It represents one of the few autosomal dominant inherited …

The promise of personalized medicine is that each patient's treatment can be optimally
tailored to their disease. In turn, their disease, as well as their response to the treatment, is …

KV7 channels, the voltage-gated K+ channels encoded by KCNQ genes, mediate
heterogeneous vascular responses in rodents. Postnatal changes in the functional …

MicroRNAs (miRNAs) have recently emerged as important regulators of ion channel
expression. We show here that select miR-106b family members repress the expression of …

Epileptic encephalopathies represent a group of disorders often characterized by refractory
seizures, regression in cognitive development, and typically poor prognosis. Dysfunction of …