Genomic information on tumors from 50 cancer types cataloged by the International Cancer
Genome Consortium (ICGC) shows that only a few well-studied driver genes are frequently …

The emergence of tissue engineering raises new possibilities for the study of complex
physiological and pathophysiological processes in vitro. Many tools are now available to …

Using quantitative models to predict the biological interactions of nanoparticles will
accelerate the translation of nanotechnology. Here, we characterized the serum protein …

Oncogenic mutations regulate signaling within both tumor cells and adjacent stromal cells.
Here, we show that oncogenic KRAS (KRAS G12D) also regulates tumor cell signaling via …

Biological systems are exquisitely sensitive to the location and timing of physiologic cues
and drugs. This spatiotemporal sensitivity presents opportunities for developing new …

Crosstalk and complexity within signaling pathways and their perturbation by oncogenes
limit component-by-component approaches to understanding human disease. Network …

Herpes zoster (shingles) causes significant morbidity in immune compromised hosts and
older adults. Whereas a vaccine is available for prevention of shingles, its efficacy declines …

Praise for the first edition:… superb, beautifully written and organized work that takes an
engineering approach to systems biology. Alon provides nicely written appendices to …

To the Editor: The generation of large-scale phosphoproteomics data sets to elucidate the
phosphorylation events associated with a given phenotype or disease condition has …

Background The acquisition of resistance to chemotherapy is a major hurdle in the
successful application of cancer therapy. Several anticancer approaches, including …