Chemical design of activatable photoacoustic probes for precise biomedical applications
Y Liu, L Teng, B Yin, H Meng, X Yin, S Huan… - Chemical …, 2022 - ACS Publications
Photoacoustic (PA) imaging technology, a three-dimensional hybrid imaging modality that
integrates the advantage of optical and acoustic imaging, has great application prospects in …
integrates the advantage of optical and acoustic imaging, has great application prospects in …
Activity‐based NIR enzyme fluorescent probes for the diagnosis of tumors and image‐guided surgery
H Li, D Kim, Q Yao, H Ge, J Chung, J Fan… - Angewandte …, 2021 - Wiley Online Library
Near‐infrared (NIR) activatable fluorescent probes have been considered to be the effective
edge tools for the investigation of cell biology and disease diagnosis because of their …
edge tools for the investigation of cell biology and disease diagnosis because of their …
Fluorogenic probes for disease-relevant enzymes
Traditional biochemical methods for enzyme detection are mainly based on antibody-based
immunoassays, which lack the ability to monitor the spatiotemporal distribution and, in …
immunoassays, which lack the ability to monitor the spatiotemporal distribution and, in …
The life of pi star: exploring the exciting and forbidden worlds of the benzophenone photophore
G Dorman, H Nakamura, A Pulsipher… - Chemical …, 2016 - ACS Publications
The widespread applications of benzophenone (BP) photochemistry in biological chemistry,
bioorganic chemistry, and material science have been prominent in both academic and …
bioorganic chemistry, and material science have been prominent in both academic and …
New approaches for dissecting protease functions to improve probe development and drug discovery
Proteases are well-established targets for pharmaceutical development because of their
known enzymatic mechanism and their regulatory roles in many pathologies. However …
known enzymatic mechanism and their regulatory roles in many pathologies. However …
Most recent advances on enzyme‐activatable optical probes for bioimaging
J Mei, H Tian - Aggregate, 2021 - Wiley Online Library
Enzymes are essential biological elements that play vital roles in many key cellular events
and physiological processes. The dysregulation of enzyme activity broadly occurs in a large …
and physiological processes. The dysregulation of enzyme activity broadly occurs in a large …
Exploring butyrylcholinesterase expression in diseases using a promising fluorescent imaging tool
L Xu, M Ma, J Li, H Yang, D Gao, P Ma… - Sensors and Actuators B …, 2023 - Elsevier
The level of butyrylcholinesterase (BChE) in living organisms is closely linked to disease
occurrence. Developing effective methods to monitor BChE levels in living systems is …
occurrence. Developing effective methods to monitor BChE levels in living systems is …
A ratiometric fluorescent probe for monitoring leucine aminopeptidase in living cells and zebrafish model
Z Zhou, F Wang, G Yang, C Lu, J Nie, Z Chen… - Analytical …, 2017 - ACS Publications
Leucine aminopeptidase (LAP) is an important cancer-related biomarker, which shows
significant overexpression in malignant tumor cells like liver cancer. Developing an effective …
significant overexpression in malignant tumor cells like liver cancer. Developing an effective …
Leucine Aminopeptidase-Mediated Multifunctional Molecular Imaging Tool for Diagnosis, Drug Evaluation, and Surgical Guidance of Liver-Related Diseases
L Xu, M Ma, J Li, D Gao, P Ma, F Zhang… - Analytical …, 2023 - ACS Publications
Traditional molecular imaging tools used for detecting liver diseases own several
drawbacks, such as poor optical performance and limited applicability. Monitoring the …
drawbacks, such as poor optical performance and limited applicability. Monitoring the …
A Dual‐Response DNA probe for simultaneously monitoring enzymatic activity and environmental pH using a nanopore
Both protease overexpression and local pH changes are key signatures of cancer. However,
the sensitive detection of protease activities and the accurate measurement of pH in a tumor …
the sensitive detection of protease activities and the accurate measurement of pH in a tumor …