How C-reactive protein structural isoforms with distinctive bioactivities affect disease progression

IM Rajab, PC Hart, LA Potempa - Frontiers in immunology, 2020 - frontiersin.org
C-reactive protein (CRP) is a widely known, hepatically synthesized protein whose blood
levels change rapidly and pronouncedly in response to any tissue damaging event …

Monomeric C-reactive protein in atherosclerotic cardiovascular disease: advances and perspectives

I Melnikov, S Kozlov, O Saburova, Y Avtaeva… - International journal of …, 2023 - mdpi.com
This review aimed to trace the inflammatory pathway from the NLRP3 inflammasome to
monomeric C-reactive protein (mCRP) in atherosclerotic cardiovascular disease. CRP is the …

C-reactive protein: the most familiar stranger

SR Ji, SH Zhang, Y Chang, HY Li, MY Wang… - The Journal of …, 2023 - journals.aai.org
C-reactive protein (CRP) is a highly conserved pentraxin with pattern recognition receptor–
like activities. However, despite being used widely as a clinical marker of inflammation, the …

C-reactive protein isoforms as prognostic markers of COVID-19 severity

B Molins, M Figueras-Roca, O Valero… - Frontiers in …, 2023 - frontiersin.org
C-reactive protein (CRP), an active regulator of the innate immune system, has been related
to COVID-19 severity. CRP is a dynamic protein undergoing conformational changes upon …

Single-molecule identification of the conformations of human C-reactive protein and its aptamer complex with solid-state nanopores

J Wu, L Liang, M Zhang, R Zhu, Z Wang… - … Applied Materials & …, 2022 - ACS Publications
Human C-reactive protein (CRP) is an established inflammatory biomarker and was proved
to be potentially relevant to disease pathology and cancer progression. A large body of …

Association of mTOR pathway and conformational alterations in C-reactive protein in neurodegenerative diseases and infections

NK Poddar, A Khan, F Fatima, A Saxena… - Cellular and molecular …, 2023 - Springer
Inflammatory biomarkers have been very useful in detecting and monitoring inflammatory
processes along with providing helpful information to select appropriate therapeutic …

Pattern recognition proteins: first line of defense against coronaviruses

CA Labarrere, GS Kassab - Frontiers in Immunology, 2021 - frontiersin.org
The rapid outbreak of COVID-19 caused by the novel coronavirus SARS-CoV-2 in Wuhan,
China, has become a worldwide pandemic affecting almost 204 million people and causing …

Associations of C-reactive protein isoforms with systemic lupus erythematosus phenotypes and disease activity

J Karlsson, J Wetterö, M Weiner, J Rönnelid… - Arthritis Research & …, 2022 - Springer
Background Systemic lupus erythematosus (SLE) is an autoimmune disease characterized
by a large production of autoantibodies and deficient clearance of cellular waste. The …

Inside-out oriented choline phosphate-based biomimetic magnetic nanomaterials for precise recognition and analysis of C-reactive protein

Z Chen, C Zhu, J Yang, M Zhang, J Yuan… - Analytical …, 2023 - ACS Publications
Phospholipid-based materials exhibit great application potential in the fields of chemistry,
biology, and pharmaceutical sciences. In this study, an inside-out oriented choline …

C-reactive protein lowers the serum level of IL-17, but not TNF-α, and decreases the incidence of collagen-induced arthritis in mice

SK Singh, A Prislovsky, DN Ngwa… - Frontiers in …, 2024 - frontiersin.org
The biosynthesis of C-reactive protein (CRP) in the liver is increased in inflammatory
diseases including rheumatoid arthritis. Previously published data suggest a protective …