Glycoconjugates are major constituents of mammalian cells that are formed via covalent
conjugation of carbohydrates to other biomolecules like proteins and lipids and often …

Since the first crystal structure determinations of αβ T cell receptors (TCRs) bound to class I
MHC-peptide (pMHC) antigens in 1996, a sizable database of 24 class I and class II …

Natural killer T (NKT) cells are innate-like T cells that rapidly produce a variety of cytokines
following T cell receptor (TCR) activation and can shape the immune response in many …

Natural killer T (NKT) cells combine features of the innate and adaptive immune systems.
Recently, it has become evident that these T cells have crucial roles in the response to …

Microsomal triglyceride transfer protein (MTP) was first identified as a major cellular protein
capable of transferring neutral lipids between membrane vesicles. Its role as an essential …

CD1 activates T cells, but the function and size of the possible human T cell repertoires that
recognize each of the CD1 antigen-presenting molecules remain unknown. Using an …

Recent studies suggest that increased T-cell and autoantibody reactivity to lipids may be
present in the autoimmune demyelinating disease multiple sclerosis. To perform large-scale …

The rules for the conserved reaction of αβ T cell receptors (TCRs) with major
histocompatibility complex (MHC) proteins plus peptides are poorly understood, probably …

The discovery of molecules capable of presenting lipid antigens, the CD1 family, and of the
T cells that recognize them, has opened a new dimensionin our understanding of cell …

Natural killer T cells express a conserved, semi-invariant αβ T cell receptor that has
specificity for self glycosphingolipids and microbial cell wall α-glycuronosylceramide …