Insights into epileptogenesis from post-traumatic epilepsy

M Pease, K Gupta, SL Moshé, DJ Correa… - Nature Reviews …, 2024 - nature.com
Post-traumatic epilepsy (PTE) accounts for 5% of all epilepsies. The incidence of PTE after
traumatic brain injury (TBI) depends on the severity of injury, approaching one in three in …

Early seizure prophylaxis in mild and moderate traumatic brain injury: a systematic review and meta-analysis

M Pease, A Mittal, S Merkaj, DO Okonkwo… - JAMA …, 2024 - jamanetwork.com
Importance Guidelines recommend seizure prophylaxis for early posttraumatic seizures
(PTS) after severe traumatic brain injury (TBI). Use of antiseizure medications for early …

Predicting posttraumatic epilepsy using admission electroencephalography after severe traumatic brain injury

M Pease, J Elmer, AZ Shahabadi, AN Mallela… - …, 2023 - Wiley Online Library
Objective Posttraumatic epilepsy (PTE) develops in as many as one third of severe traumatic
brain injury (TBI) patients, often years after injury. Analysis of early electroencephalographic …

Early post‐traumatic seizures in hospitalized patients with traumatic brain injury

HF Sødal, G Storvig, C Tverdal… - Acta Neurologica …, 2022 - Wiley Online Library
Objectives Early post‐traumatic seizures (EPTS) are a well‐known complication of traumatic
brain injury (TBI). EPTS increase the risk of secondary brain injury and may cause significant …

[HTML][HTML] Seizure susceptibility and sleep disturbance as biomarkers of epileptogenesis after experimental TBI

P Andrade, L Lara-Valderrábano, E Manninen… - Biomedicines, 2022 - mdpi.com
Objectives: We investigated whether seizure susceptibility increases over weeks–months
after experimental traumatic brain injury (TBI), and whether seizure susceptibility in rats …

Posttraumatic Epilepsy and Dementia Risk

ALC Schneider, CA Law, RF Gottesman… - JAMA …, 2024 - jamanetwork.com
Importance Although both head injury and epilepsy are associated with long-term dementia
risk, posttraumatic epilepsy (PTE) has only been evaluated in association with short-term …

Levetiracetam pharmacokinetics and brain uptake in a lateral fluid percussion injury rat model

LD Coles, PG Saletti, CP Lisgaras… - … of Pharmacology and …, 2023 - ASPET
Post-traumatic epilepsy (PTE) occurs in some patients after moderate/severe traumatic brain
injury (TBI). Although there are no approved therapies to prevent epileptogenesis …

[HTML][HTML] Adolescent traumatic brain injury leads to incremental neural impairment in middle-aged mice: role of persistent oxidative stress and neuroinflammation

Z Chen, P Wang, H Cheng, N Wang, M Wu… - Frontiers in …, 2023 - frontiersin.org
Background Traumatic brain injury (TBI) increases the risk of mental disorders and
neurodegenerative diseases in the chronic phase. However, there is limited …

International survey of antiseizure medication use in patients with complicated mild traumatic brain injury: a New York Neurotrauma Consortium Study

ZL Hickman, LA Spielman, EJ Barthélemy… - World Neurosurgery, 2022 - Elsevier
Background Seizures and epilepsy after traumatic brain injury (TBI) negatively affect quality
of life and longevity. Antiseizure medication (ASM) prophylaxis after severe TBI is associated …

EEG biomarkers for the prediction of post-traumatic epilepsy-a systematic review of an emerging field

J Pyrzowski, M Kałas… - … : European Journal of …, 2024 - Elsevier
Traumatic brain injury (TBI) is often followed by post-traumatic epilepsy (PTE), a condition
often difficult to treat and leading to a substantial decline in quality of life as well as …