Phagocytosis, the regulated uptake of large particles (> 0.5 μm in diameter), is essential for
tissue homeostasis and is also an early, critical component of the innate immune response …

Lysosome‐related organelles (LROs) comprise a diverse group of cell type‐specific,
membrane‐bound subcellular organelles that derive at least in part from the endolysosomal …

Dictyostelia are soil amoebae capable of extraordinary feats of survival, motility, chemotaxis,
and development. Characterised by their ability to transform from a single-celled organism …

Clathrin-coated vesicles transport selective integral membrane proteins from the plasma
membrane to endosomes and from the TGN to endosomes. Recycling of proteins from …

Host-cell invasion by apicomplexan parasites is extremely rapid and relies on a sequence of
events that are tightly controlled in time and space. In most Apicomplexa, the gliding motility …

Rab GTPases belong to the Ras GTPase superfamily and are key regulators of membrane
traffic. Among them, rab7 has been localized on late endosomes of NRK cells but its function …

Organelle acidification is an essential element of the endosomal-lysosomal pathway, but our
understanding of the mechanisms underlying progression through this pathway has been …

Cells use phagocytosis and macropinocytosis to internalise bulk material, which in
phagotrophic organisms supplies the nutrients necessary for growth. Wildtype Dictyostelium …

Phagocytosis, the process by which cells internalize large particulate materials from their
milieu and sequester them in phagosomes, plays a role in a variety of cell functions ranging …

Dictyostelium cells that lack the myoB isoform were previously shown to exhibit reduced
efficiencies of phagocytosis and chemotactic aggregation (" streaming") and to crawl at …