[HTML][HTML] Normal and glaucomatous outflow regulation
Glaucoma remains only partially understood, particularly at the level of intraocular pressure
(IOP) regulation. Trabecular meshwork (TM) and Schlemm's canal inner wall endothelium …
(IOP) regulation. Trabecular meshwork (TM) and Schlemm's canal inner wall endothelium …
The vital role for nitric oxide in intraocular pressure homeostasis
Catalyzed by endothelial nitric oxide (NO) synthase (eNOS) activity, NO is a gaseous
signaling molecule maintaining endothelial and cardiovascular homeostasis. Principally, NO …
signaling molecule maintaining endothelial and cardiovascular homeostasis. Principally, NO …
[HTML][HTML] Extracellular matrix stiffness and TGFβ2 regulate YAP/TAZ activity in human trabecular meshwork cells
Primary open-angle glaucoma progression is associated with increased human trabecular
meshwork (HTM) stiffness and elevated transforming growth factor beta 2 (TGFβ2) levels in …
meshwork (HTM) stiffness and elevated transforming growth factor beta 2 (TGFβ2) levels in …
ATF4 leads to glaucoma by promoting protein synthesis and ER client protein load
The underlying pathological mechanisms of glaucomatous trabecular meshwork (TM)
damage and elevation of intraocular pressure (IOP) are poorly understood. Here, we report …
damage and elevation of intraocular pressure (IOP) are poorly understood. Here, we report …
[HTML][HTML] Aqueous outflow regulation–21st century concepts
M Johnstone, C Xin, J Tan, E Martin, J Wen… - Progress in retinal and …, 2021 - Elsevier
We propose an integrated model of aqueous outflow control that employs a pump-conduit
system in this article. Our model exploits accepted physiologic regulatory mechanisms such …
system in this article. Our model exploits accepted physiologic regulatory mechanisms such …
TRPV4-Rho signaling drives cytoskeletal and focal adhesion remodeling in trabecular meshwork cells
M Lakk, D Križaj - American Journal of Physiology-Cell …, 2021 - journals.physiology.org
Intraocular pressure (IOP) is dynamically regulated by the trabecular meshwork (TM), a
mechanosensitive tissue that protects the eye from injury through dynamic regulation of …
mechanosensitive tissue that protects the eye from injury through dynamic regulation of …
[HTML][HTML] Consensus recommendation for mouse models of ocular hypertension to study aqueous humor outflow and its mechanisms
CM McDowell, K Kizhatil, MH Elliott… - … & visual science, 2022 - iovs.arvojournals.org
Due to their similarities in anatomy, physiology, and pharmacology to humans, mice are a
valuable model system to study the generation and mechanisms modulating conventional …
valuable model system to study the generation and mechanisms modulating conventional …
Developing an experimental-computational workflow to study the biomechanics of the human conventional aqueous outflow pathway
The aqueous humor actively interacts with the trabecular meshwork (TM), juxtacanalicular
tissue (JCT), and Schlemm's canal (SC) through a dynamic fluid-structure interaction (FSI) …
tissue (JCT), and Schlemm's canal (SC) through a dynamic fluid-structure interaction (FSI) …
Caveolar and non-Caveolar Caveolin-1 in ocular homeostasis and disease
EN Enyong, JM Gurley, ML De Ieso, WD Stamer… - Progress in retinal and …, 2022 - Elsevier
Caveolae, specialized plasma membrane invaginations present in most cell types, play
important roles in multiple cellular processes including cell signaling, lipid uptake and …
important roles in multiple cellular processes including cell signaling, lipid uptake and …
Rho kinase inhibitor AR-12286 reverses steroid-induced changes in intraocular pressure, effective filtration areas, and morphology in mouse eyes
R Ren, AA Humphrey, C Kopczynski… - … & Visual Science, 2023 - iovs.arvojournals.org
Purpose: We investigated mechanisms of reduction of intraocular pressure (IOP) by Rho
kinase inhibitor AR-12286 in steroid-induced ocular hypertension (SIOH). Methods …
kinase inhibitor AR-12286 in steroid-induced ocular hypertension (SIOH). Methods …