Cholesterol homeostasis is vital for proper cellular and systemic functions. Disturbed
cholesterol balance underlies not only cardiovascular disease but also an increasing …

Ferroptosis is a new type of oxidative regulated cell death (RCD) driven by iron-dependent
lipid peroxidation. As major sites of iron utilization and master regulators of oxidative …

Exosomes represent a subtype of extracellular vesicle that is released through retrograde
transport and fusion of multivesicular bodies with the plasma membrane. Although no …

Cholesterol is an essential structural component of membranes that contributes to
membrane integrity and fluidity. Cholesterol homeostasis plays a critical role in the …

In the recent years, ferroptosis, a novel non-apoptotic iron dependent form of programmed
cell death, gained lots of attention in the treatment of several disease like cancer, ischemic …

Recently, targeting metabolic reprogramming has emerged as a potential therapeutic
approach for fighting cancer. Sterol regulatory element binding protein-2 (SREBP-2), a basic …

Cholesterol is a lipid molecule that plays an essential role in a number of biological
processes, both physiological and pathological. It is an essential structural constituent of cell …

Host cholesterol metabolism remodeling is significantly associated with the spread of human
pathogenic coronaviruses, suggesting virus-host relationships could be affected by …

Macrophages acquire anti-inflammatory and proresolving functions to facilitate resolution of
inflammation and promote tissue repair. While alternatively activated macrophages (AAMs) …

Cholesterol homeostasis is related to multiple diseases in humans, including cardiovascular
disease, cancer, and neurodegenerative and hepatic diseases. The cholesterol levels in …