Tau protein plays a critical role in the assembly, stabilization, and modulation of
microtubules, which are important for the normal function of neurons and the brain. In …

The APOE4 protein affects the primary neuropathological markers of Alzheimer's disease
(AD): amyloid plaques, neurofibrillary tangles, and gliosis. These interactions have been …

Contacts between organelles create microdomains that play major roles in regulating key
intracellular activities and signaling pathways, but whether they also regulate systemic …

With an exponential increase in extracellular vesicle (EV) studies in the past decade, focus
has been placed on standardization of experimental design to ensure inter‐study …

Abstract Purpose of Review Cholesteryl ester transfer proteins (CETP) regulate plasma
cholesterol levels by transferring cholesteryl esters (CEs) among lipoproteins. Lipoprotein …

It has been proposed that the intrinsic property of nucleosome arrays to undergo liquid-liquid
phase separation (LLPS) in vitro is responsible for chromatin domain organization in vivo …

A single-molecule three-dimensional (3D) structure is essential for understanding the
thermal vibrations and dynamics as well as the conformational changes during the chemical …

Antibodies are vital for human health because of their ability to function as nature's drugs by
protecting the body from infection. In recent decades, antibodies have been used as …

Scaffolded DNA origami has proven to be a powerful and efficient technique to fabricate
functional nanomachines by programming the folding of a single-stranded DNA template …

The O-glycoprotein apolipoprotein E (APOE), the strongest genetic risk factor for Alzheimer's
disease, associates with lipoproteins. Cerebrospinal fluid (CSF) APOE binds only high …