Advances in resection and transplantation for hepatocellular carcinoma

E Vibert, M Schwartz, KM Olthoff - Journal of hepatology, 2020 - Elsevier
It would be impossible to summarise all of the significant developments in the surgical
management of hepatocellular carcinoma (HCC), even just over the past year, in a …

[HTML][HTML] Normothermic liver machine perfusion as a dynamic platform for regenerative purposes: What does the future have in store for us?

B Lascaris, VE de Meijer, RJ Porte - Journal of Hepatology, 2022 - Elsevier
Liver transplantation has become an immense success; nevertheless, far more recipients
are registered on waiting lists than there are available donor livers for transplantation. High …

Ischemia-reperfusion injury in marginal liver grafts and the role of hypothermic machine perfusion: molecular mechanisms and clinical implications

Z Czigany, I Lurje, M Schmelzle, W Schöning… - Journal of Clinical …, 2020 - mdpi.com
Ischemia-reperfusion injury (IRI) constitutes a significant source of morbidity and mortality
after orthotopic liver transplantation (OLT). The allograft is metabolically impaired during …

The future of organ perfusion and re‐conditioning

A Weissenbacher, G Vrakas, D Nasralla… - Transplant …, 2019 - Wiley Online Library
Organ preservation and re‐conditioning using machine perfusion technologies continue to
generate promising results in terms of viability assessment, organ utilization and improved …

Emerging role of NLRP3 inflammasome and pyroptosis in liver transplantation

F Lucas-Ruiz, A Peñín-Franch, JA Pons… - International journal of …, 2022 - mdpi.com
The nucleotide-binding domain leucine-rich repeat-receptor, pyrin domain-containing-3
(NLRP3) inflammasome contributes to the inflammatory response by activating caspase-1 …

Review of current machine perfusion therapeutics for organ preservation

J Xu, JE Buchwald, PN Martins - Transplantation, 2020 - journals.lww.com
Because of the high demand of organs, the usage of marginal grafts has increased. These
marginal organs have a higher risk of developing ischemia-reperfusion injury, which can …

Normothermic machine perfusion (NMP) of the liver as a platform for therapeutic interventions during ex-vivo liver preservation: a review

F Dengu, SH Abbas, G Ebeling, D Nasralla - Journal of clinical medicine, 2020 - mdpi.com
Liver transplantation is increasingly dependent on the use of extended criteria donors (ECD)
to increase the organ donor pool and address rising demand. This has necessitated the …

[HTML][HTML] RNA interference therapeutics in organ transplantation: The dawn of a new era

IMA Brüggenwirth, PN Martins - American Journal of Transplantation, 2020 - Elsevier
RNA interference (RNAi) is a natural process through which double-stranded RNA
molecules can silence the gene carrying the same code as the particular RNA of interest. In …

[HTML][HTML] Normothermic machine perfusion (NMP) of the liver–current status and future perspectives

CJ van Beekum, TO Vilz, TR Glowka… - Annals of …, 2021 - ncbi.nlm.nih.gov
A shortage of available organs for liver transplantation has led transplant surgeons and
researchers to seek for innovative approaches in hepatoprotection and improvement of …

Normothermic machine perfusion systems: where do we go from here?

S López-Martínez, C Simón, X Santamaria - Transplantation, 2024 - journals.lww.com
Normothermic machine perfusion (NMP) aims to preserve organs ex vivo by simulating
physiological conditions such as body temperature. Recent advancements in NMP system …