Krüppel‐like factor 5 (KLF5) is a member of the KLF family. Recent studies have suggested
that KLF5 regulates the expression of a large number of new target genes and participates …

Despite the development of cancer therapies, the success of most treatments has been
impeded by drug resistance. The crucial role of tumor cell plasticity has emerged recently in …

Lineage transitions are a central feature of prostate development, tumourigenesis and
treatment resistance. While epigenetic changes are well known to drive prostate lineage …

Advanced prostate cancer (PCa) often develops bone metastasis, for which therapies are
very limited and the underlying mechanisms are poorly understood. We report that bone …

Inactivation of phosphatase and tensin homolog (PTEN) is prevalent in human prostate
cancer and causes high-grade adenocarcinoma with a long latency. Cancer-associated …

Endocrine therapies for prostate cancer inhibit the androgen receptor (AR) transcription
factor. In most cases, AR activity resumes during therapy and drives progression to …

Alveolar epithelial cell fate decisions drive lung development and regeneration. Using
transcriptomic and epigenetic profiling coupled with genetic mouse and organoid models …

Contributing to organ formation and tissue regeneration, extracellular matrix (ECM)
constituents provide tissue with three-dimensional (3D) structural integrity and cellular …

Krüppel-like factors (KLFs) are DNA-binding transcriptional factors, which regulate various
pathways that pertain to development, metabolism and other cellular mechanisms. KLF5 …

Many genetic variants affect disease risk by altering context-dependent gene regulation.
Such variants are difficult to study mechanistically using current methods that link genetic …