Sulfur plays a critical role for the development and maintenance of life on earth, which is
reflected by the wealth of primary metabolites, macromolecules, and cofactors bearing this …

Aromatic polyketides have attractive biological activities and pharmacological properties.
Different from other polyketides, aromatic polyketides are characterized by their polycyclic …

Bacterial aromatic polyketides, exemplified by anthracyclines, angucyclines, tetracyclines,
and pentangular polyphenols, are a large family of natural products with diverse structures …

Tetracycline (TC) natural products possess a variety of remarkable bioactivities and diverse
structures. They are an important and fertile source for developing novel drugs. As one of the …

To combat the increasing spread of antimicrobial resistance and the shortage of novel anti-
infectives, one strategy for the development of new antibiotics is to optimize known chemical …

Many bioactive natural products are glycosylated compounds in which the sugar
components usually participate in interaction and molecular recognition of the cellular target …

A new methodology for the synthesis a C4-OH derivatives of tetracycline antibiotics of both
isomers is developed in moderate yields with mild reaction conditions. The Lewis acid …

Autophagy plays an important role in maintaining tumor cell progression and survival in
response to metabolic stress. Thus, the regulation of autophagy can be used as a strategy …

Nature has a talent for inventing a vast number of natural products, including hybrids
generated by blending different scaffolds, resulting in a myriad of bioactive chemical entities …

A genomic-based polyphasic study was undertaken to establish the taxonomic status and
biotechnological and ecological potential of a Streptomyces strain, isolate SF28T, that was …