mRNA display is a powerful biological display platform for the directed evolution of proteins
and peptides. mRNA display libraries covalently link the displayed peptide or protein …

Intracellular protein–protein interactions (PPIs) are challenging targets for traditional drug
modalities. Macrocyclic peptides (MPs) prove highly effective PPI inhibitors in vitro and can …

The LC3/GABARAP family of proteins is involved in nearly every stage of autophagy.
Inhibition of LC3/GABARAP proteins is a promising approach to blocking autophagy, which …

Cyclic peptides extend the druggable target space due to their size, flexibility, and hydrogen-
bonding capacity. However, these properties impact also their passive membrane …

Severe acne vulgaris is a common chronic inflammatory skin disease worldwide. 5-
Aminolaevulinic acid photodynamic therapy (ALA-PDT) is effective and safe for severe acne …

Autophagy is a lysosomal degradation system of cytoplasmic components that contributes to
cellular homeostasis through the turnover of various biomolecules and organelles, often in a …

Significance: Acrylamide (AA) widely exists in the environment. Studies have demonstrated
that AA has neurotoxicity and potential carcinogenicity in humans, and genotoxicity and …

Some of the most dangerous bacterial pathogens (Gram-negative and mycobacterial)
deploy a formidable secondary membrane barrier to reduce the influx of exogenous …

Due to increased drug and radiation tolerance, there is an urgent need to develop novel
anticancer agents. In our previous study, we performed a series of structural modifications of …

Protein-protein interactions (PPIs) play vital roles in normal cellular processes. Dysregulated
PPIs are involved in the process of various diseases, including cancer. Thus, these PPIs …