Directing evolution of novel ligands by mRNA display
G Kamalinia, BJ Grindel, TT Takahashi… - Chemical Society …, 2021 - pubs.rsc.org
mRNA display is a powerful biological display platform for the directed evolution of proteins
and peptides. mRNA display libraries covalently link the displayed peptide or protein …
and peptides. mRNA display libraries covalently link the displayed peptide or protein …
Targeting intracellular protein–protein interactions with macrocyclic peptides
M Buyanova, D Pei - Trends in pharmacological sciences, 2022 - cell.com
Intracellular protein–protein interactions (PPIs) are challenging targets for traditional drug
modalities. Macrocyclic peptides (MPs) prove highly effective PPI inhibitors in vitro and can …
modalities. Macrocyclic peptides (MPs) prove highly effective PPI inhibitors in vitro and can …
Structure-based design of stapled peptides that bind GABARAP and inhibit autophagy
H Brown, M Chung, A Üffing… - Journal of the …, 2022 - ACS Publications
The LC3/GABARAP family of proteins is involved in nearly every stage of autophagy.
Inhibition of LC3/GABARAP proteins is a promising approach to blocking autophagy, which …
Inhibition of LC3/GABARAP proteins is a promising approach to blocking autophagy, which …
Lessons for Oral bioavailability: how Conformationally flexible cyclic peptides enter and cross lipid membranes
Cyclic peptides extend the druggable target space due to their size, flexibility, and hydrogen-
bonding capacity. However, these properties impact also their passive membrane …
bonding capacity. However, these properties impact also their passive membrane …
ALA-PDT augments intense inflammation in the treatment of acne vulgaris by COX2/TREM1 mediated M1 macrophage polarization
P Liu, X Liu, L Zhang, G Yan, H Zhang, D Xu… - Biochemical …, 2023 - Elsevier
Severe acne vulgaris is a common chronic inflammatory skin disease worldwide. 5-
Aminolaevulinic acid photodynamic therapy (ALA-PDT) is effective and safe for severe acne …
Aminolaevulinic acid photodynamic therapy (ALA-PDT) is effective and safe for severe acne …
Autophagy and cancer: Basic mechanisms and inhibitor development
Y Hama, Y Ogasawara, NN Noda - Cancer Science, 2023 - Wiley Online Library
Autophagy is a lysosomal degradation system of cytoplasmic components that contributes to
cellular homeostasis through the turnover of various biomolecules and organelles, often in a …
cellular homeostasis through the turnover of various biomolecules and organelles, often in a …
Acrylamide-induced hepatotoxicity through oxidative stress: mechanisms and interventions
L Zhang, L Yang, Y Luo, L Dong… - Antioxidants & Redox …, 2023 - liebertpub.com
Significance: Acrylamide (AA) widely exists in the environment. Studies have demonstrated
that AA has neurotoxicity and potential carcinogenicity in humans, and genotoxicity and …
that AA has neurotoxicity and potential carcinogenicity in humans, and genotoxicity and …
Measurement of small molecule accumulation into Diderm bacteria
Some of the most dangerous bacterial pathogens (Gram-negative and mycobacterial)
deploy a formidable secondary membrane barrier to reduce the influx of exogenous …
deploy a formidable secondary membrane barrier to reduce the influx of exogenous …
[HTML][HTML] Ursolic acid derivative UA232 promotes tumor cell apoptosis by inducing endoplasmic reticulum stress and lysosomal dysfunction
W Gou, N Luo, B Yu, H Wu, S Wu, C Tian… - … Journal of Biological …, 2022 - ncbi.nlm.nih.gov
Due to increased drug and radiation tolerance, there is an urgent need to develop novel
anticancer agents. In our previous study, we performed a series of structural modifications of …
anticancer agents. In our previous study, we performed a series of structural modifications of …
Utilization of macrocyclic peptides to target protein-protein interactions in cancer
J Yang, Q Zhu, Y Wu, X Qu, H Liu, B Jiang, D Ge… - Frontiers in …, 2022 - frontiersin.org
Protein-protein interactions (PPIs) play vital roles in normal cellular processes. Dysregulated
PPIs are involved in the process of various diseases, including cancer. Thus, these PPIs …
PPIs are involved in the process of various diseases, including cancer. Thus, these PPIs …