Alcohol and the brain: neuronal molecular targets, synapses, and circuits
KP Abrahao, AG Salinas, DM Lovinger - Neuron, 2017 - cell.com
Ethanol is one of the most commonly abused drugs. Although environmental and genetic
factors contribute to the etiology of alcohol use disorders, it is ethanol's actions in the brain …
factors contribute to the etiology of alcohol use disorders, it is ethanol's actions in the brain …
The dopamine theory of addiction: 40 years of highs and lows
DJ Nutt, A Lingford-Hughes, D Erritzoe… - Nature Reviews …, 2015 - nature.com
For several decades, addiction has come to be viewed as a disorder of the dopamine
neurotransmitter system; however, this view has not led to new treatments. In this Opinion …
neurotransmitter system; however, this view has not led to new treatments. In this Opinion …
Reward processing and mood-related symptoms: An RDoC and translational neuroscience perspective
R Nusslock, LB Alloy - Journal of affective disorders, 2017 - Elsevier
Background Two objectives of the NIMH Research Domain Criteria (RDoC) initiative are to
identify (a) mechanisms that are common to multiple psychiatric disorders, and (b) …
identify (a) mechanisms that are common to multiple psychiatric disorders, and (b) …
Anatomically distinct dopamine release during anticipation and experience of peak emotion to music
Music, an abstract stimulus, can arouse feelings of euphoria and craving, similar to tangible
rewards that involve the striatal dopaminergic system. Using the neurochemical specificity of …
rewards that involve the striatal dopaminergic system. Using the neurochemical specificity of …
Drug addiction: hyperkatifeia/negative reinforcement as a framework for medications development
GF Koob - Pharmacological Reviews, 2021 - ASPET
Compulsive drug seeking that is associated with addiction is hypothesized to follow a
heuristic framework that involves three stages (binge/intoxication, withdrawal/negative affect …
heuristic framework that involves three stages (binge/intoxication, withdrawal/negative affect …
The reward circuit: linking primate anatomy and human imaging
Although cells in many brain regions respond to reward, the cortical-basal ganglia circuit is
at the heart of the reward system. The key structures in this network are the anterior …
at the heart of the reward system. The key structures in this network are the anterior …
Semaglutide reduces alcohol intake and relapse-like drinking in male and female rats
C Aranäs, CE Edvardsson, OT Shevchouk, Q Zhang… - …, 2023 - thelancet.com
Background Glucagon-like peptide1 receptor (GLP-1R) agonists have been found to reduce
alcohol drinking in rodents and overweight patients with alcohol use disorder (AUD) …
alcohol drinking in rodents and overweight patients with alcohol use disorder (AUD) …
Addiction: beyond dopamine reward circuitry
ND Volkow, GJ Wang, JS Fowler… - Proceedings of the …, 2011 - National Acad Sciences
Dopamine (DA) is considered crucial for the rewarding effects of drugs of abuse, but its role
in addiction is much less clear. This review focuses on studies that used PET to characterize …
in addiction is much less clear. This review focuses on studies that used PET to characterize …
Food and drug reward: overlapping circuits in human obesity and addiction
Both drug addiction and obesity can be defined as disorders in which the saliency value of
one type of reward (drugs and food, respectively) becomes abnormally enhanced relative to …
one type of reward (drugs and food, respectively) becomes abnormally enhanced relative to …
Addiction: decreased reward sensitivity and increased expectation sensitivity conspire to overwhelm the brain's control circuit
Based on brain imaging findings, we present a model according to which addiction emerges
as an imbalance in the information processing and integration among various brain circuits …
as an imbalance in the information processing and integration among various brain circuits …