Polydatin: a review of pharmacology and pharmacokinetics
QH Du, C Peng, H Zhang - Pharmaceutical biology, 2013 - Taylor & Francis
Context: Polydatin, also named piceid (3, 4′, 5-trihydroxystilbene-3-β-d-glucoside, PD), is a
monocrystalline compound isolated from Polygonum cuspidatum Sieb. et …
monocrystalline compound isolated from Polygonum cuspidatum Sieb. et …
Polydatin: pharmacological mechanisms, therapeutic targets, biological activities, and health benefits
Polydatin is a natural potent stilbenoid polyphenol and a resveratrol derivative with
improved bioavailability. Polydatin possesses potential biological activities predominantly …
improved bioavailability. Polydatin possesses potential biological activities predominantly …
[HTML][HTML] cGAS drives noncanonical-inflammasome activation in age-related macular degeneration
Geographic atrophy is a blinding form of age-related macular degeneration characterized by
retinal pigmented epithelium (RPE) death; the RPE also exhibits DICER1 deficiency …
retinal pigmented epithelium (RPE) death; the RPE also exhibits DICER1 deficiency …
SIRT1/3 activation by resveratrol attenuates acute kidney injury in a septic rat model
S Xu, Y Gao, Q Zhang, S Wei, Z Chen… - Oxidative Medicine …, 2016 - Wiley Online Library
Sepsis often results in damage to multiple organ systems, possibly due to severe
mitochondrial dysfunction. Two members of the sirtuin family, SIRT1 and SIRT3, have been …
mitochondrial dysfunction. Two members of the sirtuin family, SIRT1 and SIRT3, have been …
SIRT1 plays a neuroprotective role in traumatic brain injury in rats via inhibiting the p38 MAPK pathway
H Yang, Z Gu, L Li, M Maegele, B Zhou, F Li… - Acta Pharmacologica …, 2017 - nature.com
Traumatic brain injury (TBI) is a major cause of disability and death in patients who
experience a traumatic injury. Mitochondrial dysfunction is one of the main factors …
experience a traumatic injury. Mitochondrial dysfunction is one of the main factors …
[HTML][HTML] Neuroprotective effects of polydatin against mitochondrial-dependent apoptosis in the rat cerebral cortex following ischemia/reperfusion injury
Y Gao, T Chen, X Lei, Y Li, X Dai… - Molecular …, 2016 - spandidos-publications.com
The neuroprotective effect of polydatin (PD) against hemorrhagic shock-induced
mitochondrial injury has been described previously, and mitochondrial dysfunction and …
mitochondrial injury has been described previously, and mitochondrial dysfunction and …
Assessment of mitochondrial dysfunction and implications in cardiovascular disorders
Y Li, Y Ma, QY Dang, XR Fan, CT Han, SZ Xu, PY Li - Life Sciences, 2022 - Elsevier
Mitochondria play a pivotal role in cellular function, not only acting as the powerhouse of the
cell, but also regulating ATP synthesis, reactive oxygen species (ROS) production …
cell, but also regulating ATP synthesis, reactive oxygen species (ROS) production …
Polydatin–a new mitochondria protector for acute severe hemorrhagic shock treatment
X Wang, R Song, Y Chen, M Zhao… - Expert opinion on …, 2013 - Taylor & Francis
Objective: The aim of the study was find out whether neuronal mitochondrial injury does take
place in severe shock and to explore effective therapy for severe shock. Research design …
place in severe shock and to explore effective therapy for severe shock. Research design …
Polydatin Protecting Kidneys against Hemorrhagic Shock‐Induced Mitochondrial Dysfunction via SIRT1 Activation and p53 Deacetylation
Z Zeng, Z Chen, S Xu, Q Zhang, X Wang… - Oxidative Medicine …, 2016 - Wiley Online Library
Objectives. To ascertain if mitochondrial dysfunction (MD) of kidney cells is present in severe
hemorrhagic shock and to investigate whether polydatin (PD) can attenuate MD and its …
hemorrhagic shock and to investigate whether polydatin (PD) can attenuate MD and its …
Palmitoylethanolamide and Polydatin combination reduces inflammation and oxidative stress in vascular injury
Acute and chronic inflammation responses are important risk factors for vascular remodeling
processes such as in atherosclerosis, arteriosclerosis and restenosis. Inflammation and …
processes such as in atherosclerosis, arteriosclerosis and restenosis. Inflammation and …