Polydatin: a review of pharmacology and pharmacokinetics

QH Du, C Peng, H Zhang - Pharmaceutical biology, 2013 - Taylor & Francis
Context: Polydatin, also named piceid (3, 4′, 5-trihydroxystilbene-3-β-d-glucoside, PD), is a
monocrystalline compound isolated from Polygonum cuspidatum Sieb. et …

Polydatin: pharmacological mechanisms, therapeutic targets, biological activities, and health benefits

A Karami, S Fakhri, L Kooshki, H Khan - Molecules, 2022 - mdpi.com
Polydatin is a natural potent stilbenoid polyphenol and a resveratrol derivative with
improved bioavailability. Polydatin possesses potential biological activities predominantly …

[HTML][HTML] cGAS drives noncanonical-inflammasome activation in age-related macular degeneration

N Kerur, S Fukuda, D Banerjee, Y Kim, D Fu… - Nature medicine, 2018 - nature.com
Geographic atrophy is a blinding form of age-related macular degeneration characterized by
retinal pigmented epithelium (RPE) death; the RPE also exhibits DICER1 deficiency …

SIRT1/3 activation by resveratrol attenuates acute kidney injury in a septic rat model

S Xu, Y Gao, Q Zhang, S Wei, Z Chen… - Oxidative Medicine …, 2016 - Wiley Online Library
Sepsis often results in damage to multiple organ systems, possibly due to severe
mitochondrial dysfunction. Two members of the sirtuin family, SIRT1 and SIRT3, have been …

SIRT1 plays a neuroprotective role in traumatic brain injury in rats via inhibiting the p38 MAPK pathway

H Yang, Z Gu, L Li, M Maegele, B Zhou, F Li… - Acta Pharmacologica …, 2017 - nature.com
Traumatic brain injury (TBI) is a major cause of disability and death in patients who
experience a traumatic injury. Mitochondrial dysfunction is one of the main factors …

[HTML][HTML] Neuroprotective effects of polydatin against mitochondrial-dependent apoptosis in the rat cerebral cortex following ischemia/reperfusion injury

Y Gao, T Chen, X Lei, Y Li, X Dai… - Molecular …, 2016 - spandidos-publications.com
The neuroprotective effect of polydatin (PD) against hemorrhagic shock-induced
mitochondrial injury has been described previously, and mitochondrial dysfunction and …

Assessment of mitochondrial dysfunction and implications in cardiovascular disorders

Y Li, Y Ma, QY Dang, XR Fan, CT Han, SZ Xu, PY Li - Life Sciences, 2022 - Elsevier
Mitochondria play a pivotal role in cellular function, not only acting as the powerhouse of the
cell, but also regulating ATP synthesis, reactive oxygen species (ROS) production …

Polydatin–a new mitochondria protector for acute severe hemorrhagic shock treatment

X Wang, R Song, Y Chen, M Zhao… - Expert opinion on …, 2013 - Taylor & Francis
Objective: The aim of the study was find out whether neuronal mitochondrial injury does take
place in severe shock and to explore effective therapy for severe shock. Research design …

Polydatin Protecting Kidneys against Hemorrhagic Shock‐Induced Mitochondrial Dysfunction via SIRT1 Activation and p53 Deacetylation

Z Zeng, Z Chen, S Xu, Q Zhang, X Wang… - Oxidative Medicine …, 2016 - Wiley Online Library
Objectives. To ascertain if mitochondrial dysfunction (MD) of kidney cells is present in severe
hemorrhagic shock and to investigate whether polydatin (PD) can attenuate MD and its …

Palmitoylethanolamide and Polydatin combination reduces inflammation and oxidative stress in vascular injury

E Gugliandolo, R Fusco, F Biundo, R D'Amico… - Pharmacological …, 2017 - Elsevier
Acute and chronic inflammation responses are important risk factors for vascular remodeling
processes such as in atherosclerosis, arteriosclerosis and restenosis. Inflammation and …