Peroxisome proliferator-activated receptor gamma (PPARγ) is a ligand-activated nuclear
receptor that regulates glucose and lipid metabolism, endothelial function and inflammation …

Background & Aims Serotonin (5-hydroxytryptamine [5-HT]) is synthesized mainly within
enterochromaffin (EC) cells in the gut, and tryptophan hydroxylase 1 (Tph1) is the rate …

Development of the vascular disease pulmonary hypertension (PH) involves disparate
molecular pathways that span multiple cell types. MicroRNAs (miRNAs) may coordinately …

Angiogenesis, a crucial step in tumor growth and metastasis, is regulated by various pro-or
anti-angiogenic factors. Recently, microRNAs have been shown to modulate angiogenic …

Pulmonary hypertension (PH) is a complex disorder, spanning several known vascular cell
types. Recently, we identified the microRNA-130/301 (miR-130/301) family as a regulator of …

Pulmonary arterial hypertension (PAH) is a severe disease with a resultant increase of the
mean pulmonary arterial pressure, right ventricular hypertrophy and eventual death …

Abstract MicroRNA-27a (miR-27a) upregulation has been identified in diabetes, but the
pathogenesis of miR-27a in renal tubulointerstitial fibrosis (TIF) in diabetic nephropathy (DN) …

Pulmonary hypertension (PH) is a progressive complex fatal disease of multiple etiologies.
Hyperproliferation and resistance to apoptosis of vascular cells of intimal, medial, and …

Translational research is essential to the development of reverse-remodeling strategies for
the treatment of pulmonary vascular disease, pulmonary hypertension, and heart failure via …

Pulmonary hypertension (PH) is a progressive and often fatal disorder whose pathogenesis
involves pulmonary artery smooth muscle cell (PASMC) proliferation. Although modern PH …