Serotonergic modulation of the activity of mesencephalic dopaminergic systems: therapeutic implications

P De Deurwaerdère, G Di Giovanni - Progress in neurobiology, 2017 - Elsevier
Since their discovery in the mammalian brain, it has been apparent that serotonin (5-HT)
and dopamine (DA) interactions play a key role in normal and abnormal behavior …

New therapeutic opportunities for 5-HT2C receptor ligands in neuropsychiatric disorders

G Di Giovanni, P De Deurwaerdère - Pharmacology & therapeutics, 2016 - Elsevier
Abstract The 5-HT 2C receptor (R) displays a widespread distribution in the CNS and is
involved in the action of 5-HT in all brain areas. Knowledge of its functional role in the CNS …

Conductive metal–organic framework microelectrodes regulated by conjugated molecular wires for monitoring of dopamine in the mouse brain

Y Wang, Y Qian, L Zhang, Z Zhang… - Journal of the …, 2023 - ACS Publications
Herein, we demonstrated a strategy to regulate the conductive metal–organic framework
(MOF) surface, by the conjugated molecule wires for selective and sensitive determination of …

Flexible, multifunctional neural probe with liquid metal enabled, ultra-large tunable stiffness for deep-brain chemical sensing and agent delivery

X Wen, B Wang, S Huang, MS Lee, PS Chung… - Biosensors and …, 2019 - Elsevier
Flexible neural probes have been pursued previously to minimize the mechanical mismatch
between soft neural tissues and implants and thereby improve long-term performance …

N-substituted piperazines abused by humans mimic the molecular mechanism of 3, 4-methylenedioxymethamphetamine (MDMA, or 'Ecstasy')

MH Baumann, RD Clark, AG Budzynski… - …, 2005 - nature.com
Methylenedioxymethamphetamine (MDMA, or 'Ecstasy') is an illicit drug that stimulates the
release of serotonin (5-HT) and dopamine (DA) from neurons. Recent evidence reveals that …

(±) 3, 4-Methylenedioxymethamphetamine ('Ecstasy')-induced serotonin neurotoxicity: clinical studies

UD McCann, V Eligulashvili, GA Ricaurte - Neuropsychobiology, 2000 - karger.com
Abstract (±) 3, 4-Methylenedioxymethamphetamine (MDMA,'Ecstasy') is a brain serotonergic
neurotoxin in experimental animals, including nonhuman primates. It is also an increasingly …

Therapeutic and adverse actions of serotonin transporter substrates

RB Rothman, MH Baumann - Pharmacology & therapeutics, 2002 - Elsevier
A variety of drugs release serotonin (5-HT, 5-hydroxytryptamine) from neurons by acting as
substrates for 5-HT transporter (SERT) proteins. This review summarizes the neurochemical …

Methylone and mCPP, two new drugs of abuse?

M Bossong, J Van Dijk, R Niesink - Addiction biology, 2005 - Wiley Online Library
Recently, two new ecstasy‐like substances, methylone and mCPP, were found in street
drugs in the Netherlands by the Drugs Information and Monitoring System (DIMS) …

Metabolism of designer drugs of abuse

RF Staack, HH Maurer - Current drug metabolism, 2005 - ingentaconnect.com
Abuse of designer drugs is widespread among young people, especially in the so-called
“dance club scene” or “rave scene”, worldwide. Severe and even fatal poisonings have been …

Serotonin releasing agents: neurochemical, therapeutic and adverse effects

RB Rothman, MH Baumann - Pharmacology Biochemistry and Behavior, 2002 - Elsevier
This review summarizes the neurochemical, therapeutic and adverse effects of serotonin (5-
HT) releasing agents. The 5-HT releaser (±)-fenfluramine is composed of two …