Urea Hydrogen Peroxide and Ethyl Lactate, an Eco-Friendly Combo System in the Direct C(sp2)–H Bond Selenylation of Imidazo[2,1-b]thiazole and Related …

CAO Moraes, RBC Santos, MFO Cavalcante… - Acs Omega, 2023 - ACS Publications
Herein, we describe a urea hydrogen peroxide-mediated sustainable protocol for the
synthesis of selenylated imidazo [2, 1-b] thiazole by using half molar equivalent diorganyl …

Novel imidazo [2, 1-b] thiazoles and imidazo [1, 2-a] pyridines tethered with indolinone motif as VEGFR-2 inhibitors and apoptotic inducers: Design, synthesis and …

MS Elkotamy, MK Elgohary, ST Al-Rashood… - Bioorganic …, 2024 - Elsevier
The current study investigates the anticancer and VEGFR-2 inhibitory activities of 16 novel
indolinone-grafted imidazo [2, 1-b] thiazole and imidazo [1, 2-a] pyridine derivatives (6a-h …

Evaluation of 2,3-dihydroimidazo[2,1-b]oxazole and imidazo[2,1–b]oxazole derivatives as chemotherapeutic agents

AI Shahin, SO Zaraei, S Alzuraiqi… - Future Medicinal …, 2023 - Taylor & Francis
Imidazo [2, 1-b] oxazole and 2, 3-dihydroimidazo [2, 1-b] oxazole ring systems are
commonly employed in therapeutically active molecules. In this article, the authors review …

An overview of RAF kinases and their inhibitors (2019-2023)

OM Hashem, AI Shahin, MA Al Hindawi… - European Journal of …, 2024 - Elsevier
Protein kinases (PKs) including RAF, performs a principal role in regulating countless
cellular events such as cell growth, differentiation, and angiogenesis. Overexpression and …

Design, synthesis and biological evaluation of a new series of imidazothiazole-hydrazone hybrids as dual EGFR and Akt inhibitors for NSCLC therapy

MD Altıntop, İ Ertorun, GA Çiftçi, A Özdemir - European Journal of Medicinal …, 2024 - Elsevier
In search of small molecules for targeted therapy of non-small cell lung carcinoma (NSCLC),
an efficient four-step synthetic route was followed for the synthesis of new imidazothiazole …

Discovery of first-in-class imidazothiazole-based potent and selective ErbB4 (HER4) kinase inhibitors

SO Zaraei, RM Sbenati, NN Alach, HS Anbar… - European Journal of …, 2021 - Elsevier
This article reports on novel imidazothiazole derivatives as first-in-class potent and selective
ErbB4 (HER4) inhibitors. There are no other reported selective inhibitors of this kinase in the …

[PDF][PDF] Anti-cancer and antioxidant activities of some new synthesized mannich bases containing an imidazo (2, 1-B) thiazole moiety

MS Hussein, N Al-Lami - Iraqi Journal of Science, 2022 - iasj.net
Synthesis and preliminary biological evaluation of imidazo (2, 1-b) Thiazole derivatives is
reported. Under Mannich conditions, a series of new imidazo (2, 1-b) Thiazole derivatives …

Chalcone-based imidazo[2,1-b]thiazole derivatives: synthesis, crystal structure, potent anticancer activity, and computational studies

S Dadou, A Altay, C Baydere, EH Anouar… - Journal of …, 2023 - Taylor & Francis
In this work, two novel chalcone-based imidazothiazole derivatives ITC-1 and ITC-2 were
synthesized and characterized by 1H NMR, 13C NMR and high-resolution mass …

Synthesis of Benzo[4,5]thiazolo[2,3-c][1,2,4]triazole Derivatives via CH Bond Functionalization of Disulfide Intermediates

LG Ardón-Muñoz, JL Bolliger - Molecules, 2022 - mdpi.com
Many nitrogen-and sulfur-containing heterocyclic compounds exhibit biological activity.
Among these heterocycles are benzo [4, 5] thiazolo [2, 3-c][1, 2, 4] triazoles for which two …

Visible-Light-Prompted Synthesis and Binding Studies of 5,6-Dihydroimidazo[2,1-b]thiazoles with BSA and DNA Using Biophysical and Computational Methods

R Aggarwal, M Hooda, P Kumar, N Jain… - The Journal of …, 2022 - ACS Publications
Fused heterocyclic systems containing a bridgehead nitrogen atom have emerged as
imperative pharmacophores in the design and development of new drugs. Among these …