Isothermal titration calorimetry (ITC) as a promising tool in pharmaceutical nanotechnology

IDL Cavalcanti, FHX Junior, NSS Magalhães… - International Journal of …, 2023 - Elsevier
Isothermal titration calorimetry (ITC) is a technique for evaluating the thermodynamic profiles
of connection between two molecules, allowing the experimental design of nanoparticles …

Dually Active Apigenin-Loaded Nanostructured Lipid Carriers for Cancer Treatment

L Bonilla-Vidal, M Świtalska, M Espina… - International journal …, 2023 - Taylor & Francis
Purpose Cancer is one of the major causes of death worldwide affecting more than 19
million people. Traditional cancer therapies have many adverse effects and often result in …

Tuning the elasticity of nanogels improves their circulation time by evading immune cells

P Desai, R Rimal, A Florea, RA Gumerov… - Angewandte Chemie …, 2022 - Wiley Online Library
Peptide receptor radionuclide therapy is used to treat solid tumors by locally delivering
radiation. However, due to nephro‐and hepato‐toxicity, it is limited by its dosage. To amplify …

Relevant physicochemical methods to functionalize, purify, and characterize surface-decorated lipid-based nanocarriers

L Guyon, AC Groo, A Malzert-Freon - Molecular Pharmaceutics, 2020 - ACS Publications
Surface functionalization of lipid-based nanocarriers (LBNCs) with targeting ligands has
attracted huge interest in the field of nanomedicines for their ability to overcome some …

Are all poorly soluble drugs dissolved in deep eutectic solvents true solutions?

J Zhu, Y Wei, J Zhang, S Qian, Y Gao… - Journal of Colloid and …, 2023 - Elsevier
Hypothesis: The ability of deep eutectic solvents (DES) to enhance solubility of poorly
soluble drugs has attracted increasing attention. Researchers have shown that drugs could …

[HTML][HTML] Melatonin loaded nanostructured lipid carriers for the treatment of uveal melanoma

L Bonilla-Vidal, M Espina, ML García, C Cimino… - Journal of Drug Delivery …, 2024 - Elsevier
Uveal melanoma, a highly aggressive intraocular tumor and the second most common form
of ocular malignancy, currently lacks effective therapeutic options. Therefore, this study …

Binding affinity and driving forces for the interaction of calixarene-based micellar aggregates with model antibiotics in neutral aqueous solution

R Migliore, G Granata, A Rivoli, GML Consoli… - Frontiers in …, 2021 - frontiersin.org
The search for novel surfactants or drug delivery systems able to improve the performance of
old-generation antibiotics is a topic of great interest. Self-assembling amphiphilic calix [4] …

[HTML][HTML] Nanostructured lipid carriers co-encapsulating Apigenin and Melatonin: An innovative strategy against cancer

L Bonilla-Vidal, M Świtalska, M Espina, J Wietrzyk… - Materials & Design, 2024 - Elsevier
Cancer affects 9 million people every year constituting one of the main causes of death.
However, current treatments are frequently associated with adverse effects and can exhibit …

[HTML][HTML] Combination of Apigenin and Melatonin with nanostructured lipid carriers as anti-inflammatory ocular treatment

L Bonilla-Vidal, M Espina, ML García, L Baldomà… - International Journal of …, 2024 - Elsevier
Ocular inflammation is a complex pathology with limited treatment options. While traditional
therapies have side effects, novel approaches, such as natural compounds like Apigenin …

[HTML][HTML] Novel nanostructured lipid carriers loading Apigenin for anterior segment ocular pathologies

L Bonilla-Vidal, M Espina, ML García, L Baldomà… - International journal of …, 2024 - Elsevier
Dry eye disease (DED) is a chronic multifactorial disorder of the ocular surface caused by
tear film dysfunction and constitutes one of the most common ocular conditions worldwide …