The odds of living a long and healthy life with HIV infection have dramatically improved with
the advent of combination antiretroviral therapy. Along with the early development and …

Omics-based approaches have become increasingly influential in identifying disease
mechanisms and drug responses. Considering that diseases and drug responses are co …

Massive research efforts are now underway to develop a cure for HIV infection, allowing
patients to discontinue lifelong combination antiretroviral therapy (ART). New latency …

Antiretroviral therapy (ART) suppresses viral replication in people living with HIV. Yet,
infected cells persist for decades on ART and viremia returns if ART is stopped. Persistence …

A typical HIV infection response consists of three stages: an initial acute infection, a long
asymptomatic period and a final increase in viral load with simultaneous collapse in healthy …

In this monograph we consider the class of continuous-time positive switched systems. We
discuss several problems, including stability, performance analysis, stabilization via …

HIV infection can be effectively controlled by anti-retroviral therapy (ART) in most patients.
However therapy must be continued for life, because interruption of ART leads to rapid …

Monitoring the efficacy of novel reservoir-reducing treatments for HIV is challenging. The
limited ability to sample and quantify latent infection means that supervised antiretroviral …

Viral latency is a major barrier to curing HIV infection with antiretroviral therapy, and
consequently, for eliminating the disease globally. The establishment, maintenance, and …

Reverse transcription of HIV-1 results in the generation of a linear cDNA that serves as the
precursor to the integrated provirus. Other classes of extrachromosomal viral cDNA …