The sirtuins (SIRTs; of which there are seven in mammals) are NAD+-dependent enzymes
that regulate a large number of cellular pathways and forestall the progression of ageing …

Cancer initiation and progression are the result of genetic and/or epigenetic alterations.
Acetylation-mediated histone/non-histone protein modification plays an important role in the …

Reversible acetylation of histone and non-histone proteins is one of the most abundant post-
translational modifications in eukaryotic cells. Protein acetylation and deacetylation are …

Background Propolis is a resinous product that is collected from plants by bees to cover
holes and crevices in their hives. Propolis has potent antibacterial, antiviral, anti …

Abstract Sirtuins (SIRTs 1− 7), or class III histone deacetylases (HDACs), are protein
deacetylases/ADP ribosyltransferases that target a wide range of cellular proteins in the …

Among the greatest challenges facing organisms is that of detecting and effectively
responding to life-threatening environmental changes that are intimately associated with …

Gene expression and deacetylase activity of the class III histone deacetylase SIRT1 are up-
regulated in cancer cells due to oncogene overexpression or loss of function of tumor …

Despite the existence of morphologically indistinguishable disease, patients with advanced
ovarian tumors display a broad range of survival end points. We hypothesize that gene …

Evidence suggests that the histone deacetylase, SIRT1, is a mediator of life span extension
by calorie restriction; however, SIRT1 may paradoxically increase the risk of cancer. To …

Chemotherapy is the preferred treatment for malignancies. However, a successful long-term
use of chemotherapy is often prevented by the development of drug resistance. Many …