The landscape of mRNA nanomedicine
Messenger RNA (mRNA) is an emerging class of therapeutic agent for the prevention and
treatment of a wide range of diseases. The recent success of the two highly efficacious …
treatment of a wide range of diseases. The recent success of the two highly efficacious …
Inflammation, immunity, and antigen persistence in post-acute sequelae of SARS-CoV-2 infection
KL Newell, AT Waickman - Current Opinion in Immunology, 2022 - Elsevier
Highlights•Post-acute sequelae of SARS-CoV-2 (PASC) are associated with persistent
inflammation.•The antigens or other immune stimuli driving PASC are still unclear.•PASC …
inflammation.•The antigens or other immune stimuli driving PASC are still unclear.•PASC …
Understanding the pharmacology of COVID-19 mRNA vaccines: playing dice with the spike?
M Cosentino, F Marino - International journal of molecular sciences, 2022 - mdpi.com
Coronavirus disease-19 (COVID-19) mRNA vaccines are the mainstays of mass vaccination
campaigns in most Western countries. However, the emergency conditions in which their …
campaigns in most Western countries. However, the emergency conditions in which their …
Omicron variant of SARS-CoV-2 harbors a unique insertion mutation of putative viral or human genomic origin
The emergence of a heavily mutated SARS-CoV-2 variant (B. 1.1. 529, Omicron) and it's
spread to 6 continents within a week of initial discovery has set off a global public health …
spread to 6 continents within a week of initial discovery has set off a global public health …
LINE1-mediated reverse transcription and genomic integration of SARS-CoV-2 mRNA detected in virus-infected but not in viral mRNA-transfected cells
SARS-CoV-2 sequences can be reverse-transcribed and integrated into the genomes of
virus-infected cells by a LINE1-mediated retrotransposition mechanism. Whole-genome …
virus-infected cells by a LINE1-mediated retrotransposition mechanism. Whole-genome …
Cancer occurrence as the upcoming complications of COVID-19
Previous studies suggested that patients with comorbidities including cancer had a higher
risk of mortality or developing more severe forms of COVID-19. The interaction of cancer and …
risk of mortality or developing more severe forms of COVID-19. The interaction of cancer and …
Advancing mRNA Therapeutics: The Role and Future of Nanoparticle Delivery Systems
J Li, Y Zhang, YG Yang, T Sun - Molecular Pharmaceutics, 2024 - ACS Publications
The coronavirus (COVID-19) pandemic has underscored the critical role of mRNA-based
vaccines as powerful, adaptable, readily manufacturable, and safe methodologies for …
vaccines as powerful, adaptable, readily manufacturable, and safe methodologies for …
Competing endogenous RNA network mediated by circ_3205 in SARS-CoV-2 infected cells
D Barbagallo, CI Palermo, C Barbagallo… - Cellular and Molecular …, 2022 - Springer
Abstract Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is a new
member of the Betacoronaviridae family, responsible for the recent pandemic outbreak of …
member of the Betacoronaviridae family, responsible for the recent pandemic outbreak of …
Virus-induced membrane fusion in neurodegenerative disorders
C Osorio, A Sfera, JJ Anton, KG Thomas… - Frontiers in Cellular …, 2022 - frontiersin.org
A growing body of epidemiological and research data has associated neurotropic viruses
with accelerated brain aging and increased risk of neurodegenerative disorders. Many …
with accelerated brain aging and increased risk of neurodegenerative disorders. Many …
SARS-CoV-2 and the DNA damage response
RJ Grand - Journal of General Virology, 2023 - microbiologyresearch.org
The recent coronavirus disease 2019 (COVID-19) pandemic was caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2). COVID-19 is characterized by …
respiratory syndrome coronavirus 2 (SARS-CoV-2). COVID-19 is characterized by …