Microtubules are highly dynamic structures, which consist of α-and β-tubulin heterodimers,
and are involved in cell movement, intracellular trafficking, and mitosis. In the context of …

Macroautophagy is an intracellular degradation system for the majority of proteins and some
organelles. The molecular mechanism of autophagy has been extensively studied using the …

Autophagy is a bulk degradation process in eukaryotic cells and has fundamental roles in
cellular homeostasis. The origin and source of autophagosomal membranes are long …

In macroautophagy, cytoplasmic components are delivered to lysosomes for degradation via
autophagosomes that are formed by closure of cup-shaped isolation membranes. However …

Macroautophagy is a bulk degradation process induced by starvation in eukaryotic cells. In
yeast, 15 Apg proteins coordinate the formation of autophagosomes. Several key reactions …

3-Methyladenine which stops macroautophagy at the sequestration step in mammalian cells
also inhibits the phosphoinositide 3-kinase (PI3K) activity raising the possibility that PI3K …

Autophagy is a major catabolic pathway in eukaryotes, which is required for the
lysosomal/vacuolar degradation of cytoplasmic proteins and organelles. Interest in the …

The recent period has witnessed progress in the understanding of the lysosomal autophagic
pathway. The discovery of a family of genes conserved from yeast to humans, and involved …

The increasing interest in autophagy in a wide range of organisms, accompanied by an ever-
growing influx of researchers into this field, necessitates a good understanding of the …

Autophagy is a conserved and highly regulated degradative membrane trafficking pathway,
maintaining energy homeostasis and protein synthesis during nutrient stress. Our …