Importance Sickle cell disease (SCD) is a monogenic disorder, yet clinical outcomes are
influenced by additional genetic factors. Despite decades of research, the genetics of SCD …

Sickle cell disease (SCD) is an inherited monogenic disorder and the most common severe
hemoglobinopathy in the world. SCD is characterized by a point mutation in the β-globin …

The imbalance of oxidation and antioxidant systems in the biological system can lead to
oxidative stress, which is closely related to the pathogenesis of many diseases. Substances …

In sickle cell disease (SCD), recurrent painful vasoocclusive crisis are likely caused by
repeated episodes of hypoxia and reoxygenation. The sickle erythrocyte (SSRBC) adhesion …

Sickle cell disease (SCD) is an inheritable hemoglobinopathy characterized by
polymerization of hemoglobin S in red blood cells resulting in chronic hemolytic anemia …

To evaluate, in a longitudinal study, the profile of lipid peroxidation and antioxidant capacity
markers in sickle cell anaemia patients receiving different treatments and medication over …

Objectives Clinical manifestations of sickle cell disease (SCD) result from sickling of Hb S
due to oxidation, which is augmented by accumulation of oxygen-free radicals. Deficiencies …

Sickle cell disease (SCD) complications are associated with oxidative stress. Glutathione S-
transferases (GSTs) are a group of enzymes that protect against oxidative stress. The aims …

Background Busulfan (Bu) is an integral part of conditioning regimens for patients with sickle
cell anemia (SCA) undergoing transplantation. Patients with SCA might predispose to …

Sickle cell disease (SCD) is an inherited disorder of hemoglobin in which the abnormal
hemoglobin S polymerizes when deoxygenated. This polymerization of hemoglobin S not …