Infections in critically ill patients are associated with persistently poor clinical outcomes.
These patients have severely altered and variable antibiotic pharmacokinetics and are …

Therapeutic drug monitoring (TDM) opens the door to personalized medicine, yet it is
infrequently applied to β‐lactam antibiotics, one of the most commonly prescribed drug …

It is important to realize that guidelines cannot always account for individual variation among
patients. They are not intended to supplant physician judgment with respect to particular …

Background. Beta-lactam antibiotics are a commonly used treatment for severe sepsis, with
intermittent bolus dosing standard therapy, despite a strong theoretical rationale for …

Patient groups prone to polypharmacy and special subpopulations are susceptible to
suboptimal treatment. Refined dosing in special populations is imperative to improve …

Abstract Model-informed precision dosing (MIPD) stands as a significant development in
personalized medicine to tailor drug dosing to individual patient characteristics. MIPD moves …

Because of increasing antimicrobial resistance and the shortage of new antibiotics, there is
a growing need to optimize the use of old and new antibiotics. Modelling of the …

To date, the majority of pharmacokinetic/pharmacodynamic (PK/PD) discussions have
focused on PK/PD relationships evaluated at steady-state drug concentrations. However, a …

Pneumonia (draft)” was published in 1999 (1). Afterwards, a number of guidelines for
HAP/VAP have been published or updated at home and abroad (2-10). The definitions of …

A fundamental step in the successful management of sepsis and septic shock is early
empiric antimicrobial therapy. However, for this to be effective, several decisions must be …