Histological methods to assess skeletal muscle degeneration and regeneration in Duchenne muscular dystrophy

N Dubuisson, R Versele, C Planchon… - International journal of …, 2022 - mdpi.com
Duchenne muscular dystrophy (DMD) is a progressive disease caused by the loss of
function of the protein dystrophin. This protein contributes to the stabilisation of striated cells …

Computational pathology for musculoskeletal conditions using machine learning: advances, trends, and challenges

MA Konnaris, M Brendel, MA Fontana, M Otero… - Arthritis Research & …, 2022 - Springer
Histopathology is widely used to analyze clinical biopsy specimens and tissues from pre-
clinical models of a variety of musculoskeletal conditions. Histological assessment relies on …

Automatic and unbiased segmentation and quantification of myofibers in skeletal muscle

A Waisman, AM Norris, M Elías Costa, D Kopinke - Scientific reports, 2021 - nature.com
Skeletal muscle has the remarkable ability to regenerate. However, with age and disease
muscle strength and function decline. Myofiber size, which is affected by injury and disease …

Myosoft: An automated muscle histology analysis tool using machine learning algorithm utilizing FIJI/ImageJ software

L Encarnacion-Rivera, S Foltz, HC Hartzell, H Choo - PloS one, 2020 - journals.plos.org
Skeletal muscle is comprised of a heterogeneous population of muscle fibers which can be
classified by their metabolic and contractile properties (fiber “types”). Fiber type is a primary …

Effects of lycopene on skeletal muscle-fiber type and high-fat diet-induced oxidative stress

S Liu, D Yang, L Yu, Z Aluo, Z Zhang, Y Qi, Y Li… - The Journal of …, 2021 - Elsevier
Increasing studies report that many natural products can participate in formation of muscle
fibers. This study aimed to investigate the effect of lycopene on skeletal muscle-fiber type in …

Bioengineered 3D skeletal muscle model reveals complement 4b as a cell‐autonomous mechanism of impaired regeneration with aging

K Wang, SH Smith, H Iijima, ZR Hettinger… - Advanced …, 2023 - Wiley Online Library
A mechanistic understanding of cell‐autonomous skeletal muscle changes after injury can
lead to novel interventions to improve functional recovery in an aged population. However …

MyoSight—semi-automated image analysis of skeletal muscle cross sections

LW Babcock, AD Hanna, NH Agha, SL Hamilton - Skeletal muscle, 2020 - Springer
Background Manual analysis of cross-sectional area, fiber-type distribution, and total and
centralized nuclei in skeletal muscle cross sections is tedious and time consuming …

Effects of eccentric, concentric and eccentric/concentric training on muscle function and mass, functional performance, cardiometabolic health, quality of life and …

L Peñailillo, D Valladares-Ide, S Jannas-Velas… - BMC Pulmonary …, 2022 - Springer
Background Chronic obstructive pulmonary disease (COPD) is the third cause of death
worldwide. COPD is characterised by dyspnoea, limited exercise tolerance, and muscle …

General image fiber tool: A concept for automated evaluation of fiber diameters in SEM images

A Götz, V Senz, W Schmidt, J Huling, N Grabow… - Measurement, 2021 - Elsevier
Fiber imaging is becoming increasingly important in various fields. The current standard
method of quality assurance is the manual quantification of fiber diameters in Scanning …

Pathological and comprehensive genetic investigation of autopsy cases of idiopathic bradyarrhythmia

Y Hata, S Ichimata, K Hirono, Y Yamaguchi… - Circulation …, 2022 - jstage.jst.go.jp
Background: Idiopathic bradyarrhythmia is considered to be due to pathological
degeneration of the cardiac conduction system (CCS) during aging. There appears to have …