Autophagy is a conserved lysosomal pathway for the degradation of cytoplasmic
components. Basal autophagy in kidney cells is essential for the maintenance of kidney …

Diabetes induces the onset and progression of renal injury through causing hemodynamic
dysregulation along with abnormal morphological and functional nephron changes. The …

Background Everolimus permits reduced calcineurin inhibitor (CNI) exposure, but the
efficacy and safety outcomes of this treatment after kidney transplant require confirmation …

Overcoming refractory massive proteinuria remains a clinical and research issue in diabetic
nephropathy. This study was designed to investigate the pathogenesis of massive …

Diabetic kidney disease, a leading cause of end-stage renal disease, has become a serious
public health problem worldwide and lacks effective therapies. Autophagy is a highly …

Mitochondrial dysfunction has gained recognition as a contributing factor in many diseases.
The kidney is a kind of organ with high energy demand, rich in mitochondria. As such …

Inhibition of vascular endothelial growth factor A (VEGFA)/vascular endothelial growth factor
receptor 2 (VEGFR2) signaling is a common therapeutic strategy in oncology, with new …

Inhibitors of mechanistic target of rapamycin (mTOR inhibitors) are used as antiproliferative
immunosuppressive drugs and have many clinical applications in various drug …

Mammalian target of rapamycin (mTOR) inhibitors are used as potent immunosuppressive
agents in solid-organ transplant recipients (everolimus and sirolimus) and as antineoplastic …

Podocytes are highly specialized cells of the kidney glomerulus that wrap around capillaries
and that neighbor cells of the Bowman's capsule. When it comes to glomerular filtration …