Exciting new discoveries have transformed the view of the lysosome from a static organelle
dedicated to the disposal and recycling of cellular waste to a highly dynamic structure that …

Spinal cord injury (SCI) always leads to functional deterioration due to a series of processes
including cell death. In recent years, programmed cell death (PCD) is considered to be a …

Autophagy is a lysosome-dependent intracellular degradation process that allows recycling
of cytoplasmic constituents into bioenergetic and biosynthetic materials for maintenance of …

The canonical role of superoxide dismutase 1 (SOD1) is as an antioxidant enzyme
protecting the cell from reactive oxygen species toxicity. SOD1 was also the first gene in …

Amyotrophic lateral sclerosis (ALS) is an adult onset neurodegenerative disease that causes
progressive paralysis and death due to degeneration of motoneurons in spinal cord …

Recent studies of autophagic and lysosomal pathways have significantly changed our
understanding of lysosomes; once thought to be simple degradative and recycling centers …

Paget disease of bone (PDB) is a skeletal disorder common in Western Europe but
extremely rare in the Indian subcontinent and Far East. The condition has a strong genetic …

Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease
characterized by the progressive loss of motor neurons, for which current treatment options …

Many neurodegenerative conditions are characterized by the deposition of protein
aggregates (mainly amyloid-like) in the central nervous system (CNS). In post-mitotic CNS …

Neurodegenerative diseases, such as Parkinson's disease (PD), Alzheimer's disease (AD),
Huntington's disease (HD), and Amyotrophic Lateral Sclerosis (ALS), are a complex “family” …