Importance of the field: Medication use during pregnancy is prevalent, but pharmacokinetic
information of most drugs used during pregnancy is lacking in spite of known effects of …

BACKGROUND Biological covariates such as age and sex can markedly influence
biochemical marker reference values, but no comprehensive study has examined such …

The association between bilirubin (BIL) and cardiovascular disease (CVD) remains
controversial. We performed a meta-analysis of prospective studies to evaluate this …

The UDP glucuronosyltransferases (UGT) are a family of enzymes in which substrates
include drugs, xenobiotics, and products of endogenous catabolism. The main source of …

The human UDP-glucuronosyltransferase 1 (UGT1) locus spans nearly 200 kb on
chromosome 2 and encodes nine UGT1A proteins that play a prominent role in drug and …

In vitro assays are often used for the hazard characterisation of compounds, but their
application for quantitative risk assessment purposes is limited. This is because in vitro …

We have previously demonstrated that in mice, the decrease in serum thyroxine (T4) level by
polychlorinated biphenyls (PCBs) occurs without an increase in the UDP …

In male rats challenged with the environmental estrogen bisphenol A, the compound is
highly glucuronidated in the liver and is excreted largely into the bile. Given that in …

Background The impact of pregnancy on the clinical course of acute hepatitis B (AHB) is still
largely unclear, mainly because most studies have not included matched controls. This …

Human exposure to phthalic acid diesters occurs through a variety of pathways as a result of
their widespread use in plastics. Repeated doses of di-n-butylphthalate (DBP) from …