Within the canonical repertoire of the amino acid involved in protein biogenesis, proline
plays a unique role as an amino acid presenting a modified backbone rather than a side …

The goal of xenobiology is to design biological systems endowed with unusual biochemical
functions, whereas enzymology concerns the study of enzymes, the workhorses of …

Collagen model peptides (CMPs) consisting of proline‐(2S, 4R)‐hydroxyproline‐glycine
(POG) repeats have provided a breadth of knowledge of the triple helical structure of …

The incorporation of non-canonical amino acids (ncAA) is an elegant way for the chemical
diversification of recombinantly produced antimicrobial peptides (AMPs). Residue-and site …

Fluorinated prolines play an important role in peptide studies, protein engineering,
medicinal chemistry, drug discovery, and agrochemistry. Since the first synthesis of 4 …

Collagen mimics are peptides designed to reproduce structural features of natural collagen.
A triple helix is the first element in the hierarchy of collagen folding. It is an assembly of three …

Due to the heterocyclic structure and distinct conformational profile, proline is unique in the
repertoire of the 20 amino acids coded into proteins. Here, we summarize the biochemical …

The triple-helical structure of collagen, the most abundant protein in animal bodies, owes its
stability to post-translationally installed hydroxyl groups at position 4 of prolyl residues. To …

All four stereoisomers of 4-CF3O-proline have been synthesized through a
fluorodesulfurization approach using the corresponding 4-hydroxyprolines as starting …

Abstract Das Ziel der Xenobiologie ist das Design von biologischen Systemen, die mit nicht‐
natürlichen biochemischen Funktionen ausgestattet sind, während die Enzymologie sich mit …