Substrates of the methionine sulfoxide reductase system and their physiological relevance
DB Oien, J Moskovitz - Current Topics in Developmental Biology, 2007 - Elsevier
Posttranslational modifications can change a protein's structure, function, and solubility. One
specific modification caused by reactive oxygen species is the oxidation of the sulfur atom in …
specific modification caused by reactive oxygen species is the oxidation of the sulfur atom in …
Regulation of thrombosis and vascular function by protein methionine oxidation
SX Gu, JW Stevens, SR Lentz - Blood, The Journal of the …, 2015 - ashpublications.org
Redox biology is fundamental to both normal cellular homeostasis and pathological states
associated with excessive oxidative stress. Reactive oxygen species function not only as …
associated with excessive oxidative stress. Reactive oxygen species function not only as …
Differential susceptibility of plasma proteins to oxidative modification: examination by western blot immunoassay
E Shacter, JA Williams, M Lim, RL Levine - Free Radical Biology and …, 1994 - Elsevier
Plasma proteins are exposed to oxidants in a variety of circumstances in vivo, such as
during tissue injury and inflammation. In this report, the relative susceptibility of each of the …
during tissue injury and inflammation. In this report, the relative susceptibility of each of the …
Pro-thrombotic state induced by post-translational modification of fibrinogen by reactive nitrogen species
Formation of nitric oxide-derived oxidants has been linked to development of atherosclerosis
and associated thrombotic complications. Although systemic levels of protein nitrotyrosine …
and associated thrombotic complications. Although systemic levels of protein nitrotyrosine …
Oxidative modification of fibrinogen inhibits thrombin-catalyzed clot formation
E Shacter, JA Williams, RL Levine - Free Radical Biology and Medicine, 1995 - Elsevier
Plasma fibrinogen plays a central role in controlling hemostasis. In an earlier report, we
found that fibrinogen is oxidized when whole plasma is treated with a metal-catalyzed …
found that fibrinogen is oxidized when whole plasma is treated with a metal-catalyzed …
Oxidative stress and preeclampsia-associated prothrombotic state
C Han, P Huang, M Lyu, J Dong - Antioxidants, 2020 - mdpi.com
Preeclampsia (PE) is a common obstetric disease characterized by hypertension,
proteinuria, and multi-system dysfunction. It endangers both maternal and fetal health …
proteinuria, and multi-system dysfunction. It endangers both maternal and fetal health …
Singlet oxygen inactivates fibrinogen, factor V, factor VIII, factor X, and platelet aggregation of human blood
TW Stief, J Kurz, MO Doss, J Fareed - Thrombosis research, 2000 - Elsevier
Activated polymorphonuclear leukocytes participate in hemostasis. These phagocytes
generate up to 5 mmol/l of oxidants of the HOCl-and chloramine-type. The present study …
generate up to 5 mmol/l of oxidants of the HOCl-and chloramine-type. The present study …
Characterization of the glycosylation occupancy and the active site in the follow-on protein therapeutic: TNK-tissue plasminogen activator
H Jiang, SL Wu, BL Karger, WS Hancock - Analytical chemistry, 2010 - ACS Publications
TNK-tPA products from the innovator and follow-on manufacturers were characterized and
compared. All tryptic peptides including N-terminal, C-terminal, and mutated peptides as …
compared. All tryptic peptides including N-terminal, C-terminal, and mutated peptides as …
In vitro oxidative damage to tissue-type plasminogen activator: a selective modification of the biological functions
YH Feng, G Hart - Cardiovascular research, 1995 - academic.oup.com
Objective: Tissue-type plasminogen activator (t-PA) is an important component of the blood
fibrinolytic system responsible for thrombus dissolution. It is often required to function under …
fibrinolytic system responsible for thrombus dissolution. It is often required to function under …
Regulation of hemostasis by singlet-oxygen (1ΔO2*)
TW Stief - Current Vascular Pharmacology, 2004 - ingentaconnect.com
Hemostasis is the system of generation and destruction of thrombi. It consists of coagulation
and thrombolysis and has a plasmatic part and a cellular one, the latter being the …
and thrombolysis and has a plasmatic part and a cellular one, the latter being the …