Posttranslational modifications can change a protein's structure, function, and solubility. One
specific modification caused by reactive oxygen species is the oxidation of the sulfur atom in …

Redox biology is fundamental to both normal cellular homeostasis and pathological states
associated with excessive oxidative stress. Reactive oxygen species function not only as …

Plasma proteins are exposed to oxidants in a variety of circumstances in vivo, such as
during tissue injury and inflammation. In this report, the relative susceptibility of each of the …

Formation of nitric oxide-derived oxidants has been linked to development of atherosclerosis
and associated thrombotic complications. Although systemic levels of protein nitrotyrosine …

Plasma fibrinogen plays a central role in controlling hemostasis. In an earlier report, we
found that fibrinogen is oxidized when whole plasma is treated with a metal-catalyzed …

Preeclampsia (PE) is a common obstetric disease characterized by hypertension,
proteinuria, and multi-system dysfunction. It endangers both maternal and fetal health …

Activated polymorphonuclear leukocytes participate in hemostasis. These phagocytes
generate up to 5 mmol/l of oxidants of the HOCl-and chloramine-type. The present study …

TNK-tPA products from the innovator and follow-on manufacturers were characterized and
compared. All tryptic peptides including N-terminal, C-terminal, and mutated peptides as …

Objective: Tissue-type plasminogen activator (t-PA) is an important component of the blood
fibrinolytic system responsible for thrombus dissolution. It is often required to function under …

Hemostasis is the system of generation and destruction of thrombi. It consists of coagulation
and thrombolysis and has a plasmatic part and a cellular one, the latter being the …