[HTML][HTML] Biological impact and therapeutic perspective of targeting PI3K/Akt signaling in hepatocellular carcinoma: Promises and Challenges

MDA Paskeh, F Ghadyani, M Hashemi… - Pharmacological …, 2023 - Elsevier
Cancer progression results from activation of various signaling networks. Among these,
PI3K/Akt signaling contributes to proliferation, invasion, and inhibition of apoptosis …

YB‐1 protein: functions and regulation

DN Lyabin, IA Eliseeva… - Wiley Interdisciplinary …, 2014 - Wiley Online Library
The Y‐box binding protein 1 (YB‐1, YBX1) is a member of the family of DNA‐and RNA‐
binding proteins with an evolutionarily ancient and conserved cold shock domain. It falls into …

AP-1 subunits: quarrel and harmony among siblings

J Hess, P Angel, M Schorpp-Kistner - Journal of cell science, 2004 - journals.biologists.com
The AP-1 transcription factor is mainly composed of Jun, Fos and ATF protein dimers. It
mediates gene regulation in response to a plethora of physiological and pathological stimuli …

Y-box-binding protein 1 (YB-1) and its functions

IA Eliseeva, ER Kim, SG Guryanov… - Biochemistry …, 2011 - Springer
This review describes the structure and functions of Y-box binding protein 1 (YB-1) and its
homologs. Interactions of YB-1 with DNA, mRNAs, and proteins are considered. Data on the …

Calcium/calmodulin-dependent protein kinase II links ER stress with Fas and mitochondrial apoptosis pathways

JM Timmins, L Ozcan, TA Seimon, G Li… - The Journal of …, 2009 - Am Soc Clin Investig
ER stress–induced apoptosis is implicated in various pathological conditions, but the
mechanisms linking ER stress–mediated signaling to downstream apoptotic pathways …

The pleiotropic functions of the Y‐box‐binding protein, YB‐1

K Kohno, H Izumi, T Uchiumi, M Ashizuka… - …, 2003 - Wiley Online Library
The Y‐box‐binding protein (YB‐1) represents the most evolutionary conserved nucleic‐acid‐
binding protein currently known. YB‐1 is a member of the cold‐shock domain (CSD) protein …

YB-1: oncoprotein, prognostic marker and therapeutic target?

A Lasham, CG Print, AG Woolley, SE Dunn… - Biochemical …, 2013 - portlandpress.com
Hanahan and Weinberg have proposed the 'hallmarks of cancer'to cover the biological
changes required for the development and persistence of tumours [Hanahan and Weinberg …

Oncogenic H-ras reprograms Madin-Darby canine kidney (MDCK) cell-derived exosomal proteins following epithelial-mesenchymal transition

BJ Tauro, RA Mathias, DW Greening, SK Gopal… - Molecular & cellular …, 2013 - ASBMB
Epithelial-mesenchymal transition (EMT) is a highly conserved morphogenic process
defined by the loss of epithelial characteristics and the acquisition of a mesenchymal …

MaTAR25 lncRNA regulates the Tensin1 gene to impact breast cancer progression

KC Chang, SD Diermeier, AT Yu, LD Brine… - Nature …, 2020 - nature.com
Misregulation of long non-coding RNA (lncRNA) genes has been linked to a wide variety of
cancer types. Here we report on Mammary Tumor Associated RNA 25 (MaTAR25), a nuclear …

circSamd4 represses myogenic transcriptional activity of PUR proteins

PR Pandey, JH Yang, D Tsitsipatis… - Nucleic acids …, 2020 - academic.oup.com
By interacting with proteins and nucleic acids, the vast family of mammalian circRNAs is
proposed to influence many biological processes. Here, RNA sequencing analysis of …