[HTML][HTML] Biological impact and therapeutic perspective of targeting PI3K/Akt signaling in hepatocellular carcinoma: Promises and Challenges
MDA Paskeh, F Ghadyani, M Hashemi… - Pharmacological …, 2023 - Elsevier
Cancer progression results from activation of various signaling networks. Among these,
PI3K/Akt signaling contributes to proliferation, invasion, and inhibition of apoptosis …
PI3K/Akt signaling contributes to proliferation, invasion, and inhibition of apoptosis …
YB‐1 protein: functions and regulation
DN Lyabin, IA Eliseeva… - Wiley Interdisciplinary …, 2014 - Wiley Online Library
The Y‐box binding protein 1 (YB‐1, YBX1) is a member of the family of DNA‐and RNA‐
binding proteins with an evolutionarily ancient and conserved cold shock domain. It falls into …
binding proteins with an evolutionarily ancient and conserved cold shock domain. It falls into …
AP-1 subunits: quarrel and harmony among siblings
J Hess, P Angel, M Schorpp-Kistner - Journal of cell science, 2004 - journals.biologists.com
The AP-1 transcription factor is mainly composed of Jun, Fos and ATF protein dimers. It
mediates gene regulation in response to a plethora of physiological and pathological stimuli …
mediates gene regulation in response to a plethora of physiological and pathological stimuli …
Y-box-binding protein 1 (YB-1) and its functions
IA Eliseeva, ER Kim, SG Guryanov… - Biochemistry …, 2011 - Springer
This review describes the structure and functions of Y-box binding protein 1 (YB-1) and its
homologs. Interactions of YB-1 with DNA, mRNAs, and proteins are considered. Data on the …
homologs. Interactions of YB-1 with DNA, mRNAs, and proteins are considered. Data on the …
Calcium/calmodulin-dependent protein kinase II links ER stress with Fas and mitochondrial apoptosis pathways
JM Timmins, L Ozcan, TA Seimon, G Li… - The Journal of …, 2009 - Am Soc Clin Investig
ER stress–induced apoptosis is implicated in various pathological conditions, but the
mechanisms linking ER stress–mediated signaling to downstream apoptotic pathways …
mechanisms linking ER stress–mediated signaling to downstream apoptotic pathways …
The pleiotropic functions of the Y‐box‐binding protein, YB‐1
K Kohno, H Izumi, T Uchiumi, M Ashizuka… - …, 2003 - Wiley Online Library
The Y‐box‐binding protein (YB‐1) represents the most evolutionary conserved nucleic‐acid‐
binding protein currently known. YB‐1 is a member of the cold‐shock domain (CSD) protein …
binding protein currently known. YB‐1 is a member of the cold‐shock domain (CSD) protein …
YB-1: oncoprotein, prognostic marker and therapeutic target?
Hanahan and Weinberg have proposed the 'hallmarks of cancer'to cover the biological
changes required for the development and persistence of tumours [Hanahan and Weinberg …
changes required for the development and persistence of tumours [Hanahan and Weinberg …
Oncogenic H-ras reprograms Madin-Darby canine kidney (MDCK) cell-derived exosomal proteins following epithelial-mesenchymal transition
Epithelial-mesenchymal transition (EMT) is a highly conserved morphogenic process
defined by the loss of epithelial characteristics and the acquisition of a mesenchymal …
defined by the loss of epithelial characteristics and the acquisition of a mesenchymal …
MaTAR25 lncRNA regulates the Tensin1 gene to impact breast cancer progression
Misregulation of long non-coding RNA (lncRNA) genes has been linked to a wide variety of
cancer types. Here we report on Mammary Tumor Associated RNA 25 (MaTAR25), a nuclear …
cancer types. Here we report on Mammary Tumor Associated RNA 25 (MaTAR25), a nuclear …
circSamd4 represses myogenic transcriptional activity of PUR proteins
By interacting with proteins and nucleic acids, the vast family of mammalian circRNAs is
proposed to influence many biological processes. Here, RNA sequencing analysis of …
proposed to influence many biological processes. Here, RNA sequencing analysis of …