The transformation from normal to malignant phenotype in human cancers is associated with
aberrant cell-surface glycosylation. It has frequently been reported that MUC1, the heavily …

Glycans are key players in many biological processes. They are essential for protein folding
and stability and act as recognition elements in cell–cell and cell–matrix interactions. Thus …

Phosphorylation and dephosphorylation of proteins by kinases and phosphatases are
central to cellular responses and function. The structural effects of serine and threonine …

Simple Summary Glycosylation is one of the most pivotal post-translational modifications on
all types of biomolecules for the formation of glycoproteins, glycolipids, and glycoRNAs in a …

Antibodies are used extensively for a wide range of basic research and clinical applications.
While an abundant and diverse collection of antibodies to protein antigens have been …

Conspectus N-Acetylgalactosamine (GalNAc)-type O-glycosylation is an essential
posttranslational modification (PTM) that plays fundamental roles in biology. Malfunction of …

Gastrointestinal cancers (GI) account for 26% of cancer incidences globally and 35% of all
cancer-related deaths. The main challenge is to target cancer specific antigens. Mucins are …

Cancer is currently one of the world's most serious public health problems. Significant efforts
are being made to develop new strategies that can eradicate tumours selectively without …

Abstract Programmed cell death 1 (PD-1) is inhibitory receptor and immune checkpoint
protein. Blocking the interaction of PD-1 and its ligands PD-L1/L2 is able to active T-cell …

Mucins and mucin-like molecules are highly O-glycosylated proteins present on the cell
surface of mammals and other organisms. These glycoproteins are highly diverse in the …