[HTML][HTML] The role of metabolism in chondrocyte dysfunction and the progression of osteoarthritis
L Zheng, Z Zhang, P Sheng, A Mobasheri - Ageing research reviews, 2021 - Elsevier
Osteoarthritis (OA) is a degenerative joint disease characterized by low-grade inflammation
and high levels of clinical heterogeneity. Aberrant chondrocyte metabolism is a response to …
and high levels of clinical heterogeneity. Aberrant chondrocyte metabolism is a response to …
Overview of MMP-13 as a promising target for the treatment of osteoarthritis
Q Hu, M Ecker - International journal of molecular sciences, 2021 - mdpi.com
Osteoarthritis (OA) is a common degenerative disease characterized by the destruction of
articular cartilage and chronic inflammation of surrounding tissues. Matrix metalloproteinase …
articular cartilage and chronic inflammation of surrounding tissues. Matrix metalloproteinase …
NF-κB signaling pathways in osteoarthritic cartilage destruction
MC Choi, J Jo, J Park, HK Kang, Y Park - Cells, 2019 - mdpi.com
Osteoarthritis (OA) is a type of joint disease associated with wear and tear, inflammation,
and aging. Mechanical stress along with synovial inflammation promotes the degradation of …
and aging. Mechanical stress along with synovial inflammation promotes the degradation of …
Whole aspect of Runx2 functions in skeletal development
T Komori - International Journal of Molecular Sciences, 2022 - mdpi.com
Runt-related transcription factor 2 (Runx2) is a fundamental transcription factor for bone
development. In endochondral ossification, Runx2 induces chondrocyte maturation …
development. In endochondral ossification, Runx2 induces chondrocyte maturation …
Osteoarthritis: toward a comprehensive understanding of pathological mechanism
Osteoarthritis (OA) is the most common degenerative joint disease and a major cause of
pain and disability in adult individuals. The etiology of OA includes joint injury, obesity …
pain and disability in adult individuals. The etiology of OA includes joint injury, obesity …
Runx2, an inducer of osteoblast and chondrocyte differentiation
T Komori - Histochemistry and cell biology, 2018 - Springer
Runx2 is a transcription factor that is essential for osteoblast differentiation and chondrocyte
maturation. Ihh, expressed in prehypertrophic and hypertrophic chondrocytes, is required for …
maturation. Ihh, expressed in prehypertrophic and hypertrophic chondrocytes, is required for …
Redox and NF-κB signaling in osteoarthritis
P Lepetsos, KA Papavassiliou… - Free Radical Biology and …, 2019 - Elsevier
Human cells have to deal with the constant production of reactive oxygen species (ROS).
Although ROS overproduction might be harmful to cell biology, there are plenty of data …
Although ROS overproduction might be harmful to cell biology, there are plenty of data …
[HTML][HTML] Molecular mechanism of Runx2-dependent bone development
T Komori - Molecules and cells, 2020 - Elsevier
Runx2 is an essential transcription factor for skeletal development. It is expressed in
multipotent mesenchymal cells, osteoblast-lineage cells, and chondrocytes. Runx2 plays a …
multipotent mesenchymal cells, osteoblast-lineage cells, and chondrocytes. Runx2 plays a …
Hypertrophic chondrocytes can become osteoblasts and osteocytes in endochondral bone formation
L Yang, KY Tsang, HC Tang… - Proceedings of the …, 2014 - National Acad Sciences
According to current dogma, chondrocytes and osteoblasts are considered independent
lineages derived from a common osteochondroprogenitor. In endochondral bone formation …
lineages derived from a common osteochondroprogenitor. In endochondral bone formation …
New insights on the MMP-13 regulatory network in the pathogenesis of early osteoarthritis
H Li, D Wang, Y Yuan, J Min - Arthritis research & therapy, 2017 - Springer
Osteoarthritis (OA) is the most common joint disorder and affects approximately half of the
aged population. Current treatments for OA are largely palliative until the articular cartilage …
aged population. Current treatments for OA are largely palliative until the articular cartilage …