Osteoarthritis (OA) is a degenerative joint disease characterized by low-grade inflammation
and high levels of clinical heterogeneity. Aberrant chondrocyte metabolism is a response to …

Osteoarthritis (OA) is a common degenerative disease characterized by the destruction of
articular cartilage and chronic inflammation of surrounding tissues. Matrix metalloproteinase …

Osteoarthritis (OA) is a type of joint disease associated with wear and tear, inflammation,
and aging. Mechanical stress along with synovial inflammation promotes the degradation of …

Runt-related transcription factor 2 (Runx2) is a fundamental transcription factor for bone
development. In endochondral ossification, Runx2 induces chondrocyte maturation …

Osteoarthritis (OA) is the most common degenerative joint disease and a major cause of
pain and disability in adult individuals. The etiology of OA includes joint injury, obesity …

Runx2 is a transcription factor that is essential for osteoblast differentiation and chondrocyte
maturation. Ihh, expressed in prehypertrophic and hypertrophic chondrocytes, is required for …

Human cells have to deal with the constant production of reactive oxygen species (ROS).
Although ROS overproduction might be harmful to cell biology, there are plenty of data …

Runx2 is an essential transcription factor for skeletal development. It is expressed in
multipotent mesenchymal cells, osteoblast-lineage cells, and chondrocytes. Runx2 plays a …

According to current dogma, chondrocytes and osteoblasts are considered independent
lineages derived from a common osteochondroprogenitor. In endochondral bone formation …

Osteoarthritis (OA) is the most common joint disorder and affects approximately half of the
aged population. Current treatments for OA are largely palliative until the articular cartilage …