mTOR as regulator of lifespan, aging, and cellular senescence: a mini-review
T Weichhart - Gerontology, 2018 - karger.com
The mechanistic target of rapamycin (mTOR) network is an evolutionary conserved signaling
hub that senses and integrates environmental and intracellular nutrient and growth factor …
hub that senses and integrates environmental and intracellular nutrient and growth factor …
Effect of rapamycin on aging and age-related diseases—past and future
R Selvarani, S Mohammed, A Richardson - Geroscience, 2021 - Springer
In 2009, rapamycin was reported to increase the lifespan of mice when implemented later in
life. This observation resulted in a sea-change in how researchers viewed aging. This was …
life. This observation resulted in a sea-change in how researchers viewed aging. This was …
Cancer immunotherapy comes of age
Activating the immune system for therapeutic benefit in cancer has long been a goal in
immunology and oncology. After decades of disappointment, the tide has finally changed …
immunology and oncology. After decades of disappointment, the tide has finally changed …
mTOR regulates T cell exhaustion and PD-1–targeted immunotherapy response during chronic viral infection
S Ando, CM Perkins, Y Sajiki… - The Journal of …, 2023 - Am Soc Clin Investig
T cell exhaustion is a state of T cell dysfunction associated with expression of programmed
death 1 (PD-1). Exhausted CD8+ T cells are maintained by self-renewing stem-like T cells …
death 1 (PD-1). Exhausted CD8+ T cells are maintained by self-renewing stem-like T cells …
Regulation and function of mTOR signalling in T cell fate decisions
H Chi - Nature reviews immunology, 2012 - nature.com
The evolutionarily conserved kinase mTOR (mammalian target of rapamycin) couples cell
growth and metabolism to environmental inputs in eukaryotes. T cells depend on mTOR …
growth and metabolism to environmental inputs in eukaryotes. T cells depend on mTOR …
mTOR inhibition improves immune function in the elderly
JB Mannick, G Del Giudice, M Lattanzi… - Science translational …, 2014 - science.org
Inhibition of the mammalian target of rapamycin (mTOR) pathway extends life span in all
species studied to date, and in mice delays the onset of age-related diseases and …
species studied to date, and in mice delays the onset of age-related diseases and …
[HTML][HTML] Rapamycin for longevity: opinion article
MV Blagosklonny - Aging (Albany NY), 2019 - ncbi.nlm.nih.gov
From the dawn of civilization, humanity has dreamed of immortality. So why didn't the
discovery of the anti-aging properties of mTOR inhibitors change the world forever? I will …
discovery of the anti-aging properties of mTOR inhibitors change the world forever? I will …
[HTML][HTML] From causes of aging to death from COVID-19
MV Blagosklonny - Aging (Albany NY), 2020 - ncbi.nlm.nih.gov
COVID-19 is not deadly early in life, but mortality increases exponentially with age, which is
the strongest predictor of mortality. Mortality is higher in men than in women, because men …
the strongest predictor of mortality. Mortality is higher in men than in women, because men …
Regulation of immune responses by mTOR
JD Powell, KN Pollizzi, EB Heikamp… - Annual review of …, 2012 - annualreviews.org
mTOR is an evolutionarily conserved serine/threonine kinase that plays a central role in
integrating environmental cues in the form of growth factors, amino acids, and energy. In the …
integrating environmental cues in the form of growth factors, amino acids, and energy. In the …
Roles of mTOR complexes in the kidney: implications for renal disease and transplantation
D Fantus, NM Rogers, F Grahammer… - Nature Reviews …, 2016 - nature.com
The mTOR pathway has a central role in the regulation of cell metabolism, growth and
proliferation. Studies involving selective gene targeting of mTOR complexes (mTORC1 and …
proliferation. Studies involving selective gene targeting of mTOR complexes (mTORC1 and …